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All Journal JOURNAL LA MEDIHEALTICO Journal of Asian-african Focus in Health
Indah Lestari Daeng Kanang
Department of Internal Medicine, Faculty of Medicine, Universitas Muslim Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Vitamin E Supplementation and Its Impact on Pulmonary Tuberculosis Treatment Outcomes: A Systematic Review Adhelia Zalsabilah Basir; Edward Pandu Wiriansya; Suciati Damopolii; Hasan Hasan; Indah Lestari Daeng Kanang
Journal La Medihealtico Vol. 6 No. 6 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i6.2776

Abstract

Pulmonary tuberculosis remains a global health problem, and antioxidant deficiencies such as vitamin E contribute to increased oxidative stress in patients. The aim of this study was to assess the effect of vitamin E supplementation on the effectiveness of pulmonary tuberculosis treatment through a systematic review based on PRISMA 2020 guidelines. This systematic review included clinical and observational studies investigating the relationship between vitamin E and pulmonary tuberculosis. Literature searches were conducted in PubMed and Google Scholar (2008–2021) using the keywords “Vitamin E,” “Tuberculosis,” and “Lung.” Methodological quality was assessed using the JBI Checklist and Cochrane RoB2. The process was carried out at the Faculty of Medicine, Muslim University of Indonesia, Makassar, from March to August 2024. Secondary data from published studies were used; therefore, ethical approval was not required. Six studies met the inclusion criteria, consisting of two randomized controlled trials, two in vitro studies, one case–control study, and one cross-sectional study. The synthesis results showed that vitamin E supplementation consistently reduced oxidative stress, as indicated by a significant decrease in malondialdehyde (MDA) levels and an increase in enzyme activity. In addition, vitamin E improved inflammatory status through reduced C-reactive protein (CRP) levels and increased serum leptin, as well as enhanced cellular immune responses through elevated IL-2 and IFN-γ levels. Overall, vitamin E supplementation contributed to improved treatment effectiveness and quality of life in patients with pulmonary tuberculosis.Vitamin E supplementation has potential as an adjuvant therapy that enhances the effectiveness of pulmonary tuberculosis treatment through antioxidant and immunomodulatory mechanisms.
Literature Review: The Impact of Obesity on the Incidence of Osteoarthritis Nabila Aulia; Indah Lestari Daeng Kanang; Hassma Idris Nohong
Journal of Asian-african Focus in Health Vol. 4 No. 2 (2026): Journal of Asian-african Focus in Health
Publisher : ScieClouds Publishing

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Abstract

Osteoarthritis is a chronic degenerative joint disease that is one of the main causes of pain, activity limitations, and disability in adults and the elderly. Obesity is known to be an important risk factor that plays a role in the occurrence and progression of osteoarthritis through biomechanical and inflammatory mechanisms. The increasing prevalence of obesity in various countries makes the relationship between obesity and osteoarthritis a health problem that requires attention. The purpose of this study was to determine the relationship between obesity and the incidence of osteoarthritis based on the results of published studies. This study used a literature review method by examining scientific articles obtained from the PubMed, Google Scholar, ScienceDirect, SpringerLink, ProQuest, and ResearchGate databases. The selected articles were published between 2016–2026, available in Indonesian or English, and discussed the relationship between obesity and osteoarthritis. Analysis was conducted using a narrative approach and the PICOS framework on 10 articles that met the inclusion criteria. The results showed that all articles analyzed showed a relationship between obesity and osteoarthritis, especially knee osteoarthritis. Individuals with obesity have a higher risk of developing osteoarthritis than individuals of normal weight. The risk increases with increasing body mass index (BMI). In addition to increasing the mechanical load on joints, obesity also triggers chronic inflammation through the production of adipokines and proinflammatory cytokines that accelerate cartilage damage. Obesity is associated with increased pain, decreased physical function, decreased quality of life, and an increased risk of sarcopenia in osteoarthritis patients. Weight loss, physical exercise, and bariatric surgery have been shown to significantly improve symptoms and joint function. Obesity is an important risk factor associated with the occurrence and progression of osteoarthritis through biomechanical and inflammatory mechanisms. Weight control through a healthy lifestyle, regular physical activity, and weight loss interventions is an important strategy in the prevention and management of osteoarthritis.
Co-Authors Adhelia Zalsabilah Basir Edward Pandu Wiriansya Hasan Hasan Hassma Idris Nohong Nabila Aulia Suciati Damopolii