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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Indra Indra
a:1:{s:5:"en_US";s:87:"Prodi Farmasi, Fakultas Farmasi, Universitas Bakti Tunas Husada, Tasikmalaya, Indonesia";}
Medicine & Pharmacology

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Enhancing Solubility and Dissolution of Caffeine Through Solid Dispersions with Polyvinylpyrrolidone K-30: A Comparative Study of Drug-to-Polymer Ratios Indra Indra; Rian Andrianto; Ratih Aryani
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.12695

Abstract

Despite its inherently high aqueous solubility, caffeine demonstrates inconsistent oral bioavailability due to formulation and processing-related limitations. This study aimed to improve the solubility and dissolution rate of caffeine by formulating solid dispersions using polyvinylpyrrolidone K-30 (PVP K-30) via the solvent evaporation method. Solid dispersions were prepared at drug-to-polymer ratios of 1:1, 1:2, and 2:1, and characterized using hot-stage microscopy (HSM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) analysis. Solubility and dissolution testing were conducted in phosphate buffer (pH 6.8). The results showed that the 1:2 ratio formulation yielded the most significant improvement, with solubility reaching 22.3 mg/mL and a dissolution rate of 97.6% within 30 minutes, representing a substantial enhancement compared to pure caffeine. FTIR and DSC indicated the presence of hydrogen bonding and the absence of caffeine melting peak, while PXRD confirmed amorphization. These findings suggest that solid dispersion with PVP K-30 is a viable strategy for overcoming the bioavailability challenges of caffeine and similar compounds, warranting further investigation into in vivo performance and long-term stability.
Co-Authors Ratih Aryani Rian Andrianto