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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Ratih Aryani, Ratih
Program Studi S1 Farmasi STIkes Bakti Tunas Husada Tasikmalaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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The Effect of Prebiotic Starch and Pectin from Ambon Banana Peel (musa acuminata aaa) on the Growth of Skin Microbiota Bacteria In Vitro Rusdi, Bertha; Aryani, Ratih; Yuniarni, Umi
Pharmacology and Clinical Pharmacy Research Vol 8, No 2 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i2.49261

Abstract

Propionibacterium acnes is a bacteria which causes acne. This bacteria is hypothesized to be inhibited by Staphylococcus epidermidis. Prebiotics have been shown to enhance the number of S. epidermidis and decrease the growth of P. acnes. The prebiotic action of starch and pectin from diverse plant sources is known in the skin microbiome. The prebiotic activity of Ambon banana peel starch and pectin on skin microbiota has not been researched. This study aims to investigate the prebiotic activity of starch and pectin from Ambon banana peels on skin microbiota, represented by S.epidermidis and P.acnes. The results showed that starch, and pectin have a prebiotic activity because they promoted the growth of S. epidermidis while suppressing the growth of P. acnes. P. acnes inhibitor percentages were 1.62% for starch and 65.07% for pectin. Negative inhibition values were -184.95% for starch and -5.80% for pectin suggesting an increase in S. epidermidis proliferation.
Formulasi dan Karakterisasi SNEDDS (Self Nanoemulsifying Drug Delivery System) Mengandung Minyak Jintan Hitam dan Minyak Zaitun Priani, Sani Ega; Somantri, Sri Yulianingsih; Aryani, Ratih
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 1 (2020): J Sains Farm Klin 7(1), April 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.1.31-38.2020

Abstract

Self Nanoemulsifying Drug Delivery System (SNEDDS) diketahui mampu meningkatkan absorbsi oral dari senyawa senyawa hidrofob. Penelitian ini bertujuan untuk memformulasi dan mengkarakterisasi sediaan SNEDDS mengandung kombinasi minyak jintan hitam dan minyak zaitun. Penelitian diawali dengan analisis kandungan senyawa pada minyak jintan hitam dan minyak zaitun dengan metode Gas Chromatography Mass Spectrophotometry (GC-MS). Optimasi formula dilakukan dengan variasi konsentrasi minyak, surfaktan, dan kosurfaktan. Sediaan SNEDDS selanjutnya dikarakterisasi dengan pengujian persen transmitan, dispersibilitas, robustness, termodinamika (sentrifugasi, heating cooling cycle, freeze thaw cycle), penentuan ukuran serta morfologi globul nanoemulsi. Formula SNEDDS terbaik mengandung surfaktan cremophor RH 40 dan kosurfaktan PEG 400 (3:2) dengan perbandingan fase minyak dan campuran surfaktan kosurfaktan 1:7. Sediaan tersebut memenuhi persyaratan persen transmitan (97,27 ± 0,06%), uji dispersibilitas (grade A), stabil pada pengujian robustness dan termodinamika. Sediaan SNEDDS mampu membentuk nanoemulsi secara spontan dengan rata-rata ukuran globul 99 nm dengan globul berbentuk sferis. Studi ini menyimpulkan bahwa sediaan SNEDDS yang mengandung minyak jintan hitam dan minyak zaitun pada formula optimum memiliki karakteristik fisik yang baik.
Pelatihan Teknologi Ekstraksi Rimpang Jahe (Zingiber officinale) pada Masyarakat Kampung Jahe Kelurahan Karasak-Astanaanyar: Ginger (Zingiber officinale) Rhizome Extraction Technology Coaching for the people of Kampung Jahe, Karasak-Astanaanyar Sub District Aryani, Ratih; Yuliawati, Kiki Mulkiya; Lukmayani, Yani; Lestari, Fetri; Sadiyah, Esti Rachmawati; Aprilia, Hilda
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 4 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i4.7040

Abstract

The people of Ginger Village at Karasak Urban Village support the urban greening program by planting ginger plants in the yards and roadsides. Ginger is a traditional medicinal plant commodity that has the potential to be cultivated and developed into health products because of its various pharmacological effects. The PkM team has conducted Community Service Activities for active PKK cadres in Jahe village. This activity aims to educate residents of Ginger Village through PKK cadres about the importance of knowing reasonable ginger extraction procedures so that the benefits of ginger can be optimal as a nutritious ingredient with pharmacological effects. The service method is training in processing ginger using the infusion method. The results showed an increase in participants' knowledge of up to 67%, which indicates that PKK cadres could understand how to extract ginger correctly to maintain its quality and properties.
Prebiotic effect of purple sweet potato resistant starch and the development of its mucoadhesive granule formulation Yuniarni, Umi; Aryani, Ratih; Rusdi, Bertha; Nabilla, Qori
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.29581

Abstract

Purple sweet potatoes are recognized for their prebiotic properties including againts Lactobacillus casei and L. bulgaricus bacteria. This prebiotic effect is due to the high starch content in purple sweet potatoes. The amylose content in starch which is difficult to digest in gastointestinal tract, functions as a prebiotic. To enhance the prebiotic effect of purple sweet potato starch, modification into resistant starch can be performed. Resistant starch exhibits a higher prebiotic effect compared to regular starch because it cannot be broken down by digestive enzymes, allowing it to reach the large intestine in significant amounts. Additionally, the prebiotic effect can be further enhanced by creating mucoadhesive granule formulations that increase the contact time of a substance on the mucosa of the digestive tract. This study aims to evaluate the prebiotic effect of resistant starch from purple sweet potatoes and to develop its mucoadhesive granule formulation. The resistant starch from purple sweet potatoes was prepared using the heat moisture treatment method. The prebiotic activity of resistant starch was tested against Lactobacillus acidophilus and Escherichia coli. The granule formulation was prepared by varying the concentration of polymers used, namely a combination of HPMC and carbopol as mucoadhesive polymers. The results showed that resistant starch from purple sweet potatoes had a prebiotic index of 0.930. The granule formulation F3 with an HPMC and Carbopol polymer ratio of 1:2 was identified as a good mucoadhesive granule formulation. It met pharmaceutical evaluation with a mucoadhesive percentage value of 40%.
Development of Nanocapsules Containing Cytotoxic Agents- A Review: Kajian Literatur Pengembangan Sediaan Nanokapsul Mengandung Agen Sitotoksik Priani, Sani Ega; Setianty, Tia Nur; Aryani, Ratih; Fitrianingsih, Sri Peni; Syafnir, Livia
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15578

Abstract

Background: The incidence and mortality of cancer are rapidly growing worldwide. Modification on drug delivery systems based on nanotechnology was applied to improve the effectiveness and safety of treatment. Nanoencapsulation, a part of nanotechnology, was known can be involved in cytotoxic agents. Objective: This research was conducted to determine the type of polymers for nanoencapsulation of cytotoxic agents and analyze the effect of nanoencapsulation on the cytotoxic activity. Methods: The study was performed by systematic literature review using selected articles from reputable databases that meet the inclusion and exclusion criteria. Results: The results show that many cytotoxic agents have been developed in nanocapsules systems due to their low water solubility, chemical instability, and low bioavailability. The nanoencapsulation process was carried out using synthetic or natural polymers such as polylactic-co-glycolic acid (PLGA), PEGylated PLGA, polycaprolactone (PCL), chitosan-sodium tripolyphosphate, chitosan-sodium alginate, heparin-poly(l-lysine), and polymethyl methacrylate (PMMA). Those polymers are widely used for nanoencapsulation related to their biocompatible, biodegradable, non-toxic, and providing the desired coating properties. The nanoencapsulation on cytotoxic agents significantly increases the in vitro cytotoxicity, marked by the decrease of IC50 value in the range 1.4-15.4 folds compared to pure drugs. The increase in cytotoxicity could be caused by particle size reduction, modification of particle surface properties, and enhancement of drug stability. Conclusion: It can be concluded that nanoencapsulation can be applied for cytotoxic agents to increase their activity using the appropriate coating polymer.
Formulation of Green Tea Spray Gel as Supportive Therapy for Diabetic Foot Infection Priani, Sani Ega; Efrida, Delfiana Aura; Aryani, Ratih; Mulkiya, Kiki; Syafnir, Livia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.54042

Abstract

Diabetic foot infection (DFI) is a common complication of diabetes, most frequently caused by Staphylococcus aureus. Green tea contains antibacterial compounds and may serve as a potential supportive therapy for DFI. This study aimed to develop a spray gel formulation containing green tea ethanol extract and evaluate its antibacterial activity against S. aureus. The extract was obtained using 96% ethanol through the reflux method and subsequently tested for antibacterial activity using the agar well diffusion method. The extract was incorporated into a spray gel formulation with Viscolam MAC 10 as the gelling agent. The resulting spray gels were evaluated for their physical properties and antibacterial activity. Green tea extract demonstrated antibacterial activity against S. aureus with a minimum inhibitory concentration (MIC) of 0.1%. Furthermore, the ethanol extract was successfully formulated into a spray gel using 5% Viscolam MAC 10, meeting quality requirements in terms of organoleptic properties, pH, viscosity, spray pattern, spray weight, drying time, and adhesion time. Formulations containing 0.75% and 1% GTE exhibited potent antibacterial activity against S. aureus. In conclusion, a green tea–based spray gel formulation with good physical characteristics and potent antibacterial activity has been successfully developed.
Enhancing Solubility and Dissolution of Caffeine Through Solid Dispersions with Polyvinylpyrrolidone K-30: A Comparative Study of Drug-to-Polymer Ratios Indra, Indra; Andrianto, Rian; Aryani, Ratih
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.12695

Abstract

Despite its inherently high aqueous solubility, caffeine demonstrates inconsistent oral bioavailability due to formulation and processing-related limitations. This study aimed to improve the solubility and dissolution rate of caffeine by formulating solid dispersions using polyvinylpyrrolidone K-30 (PVP K-30) via the solvent evaporation method. Solid dispersions were prepared at drug-to-polymer ratios of 1:1, 1:2, and 2:1, and characterized using hot-stage microscopy (HSM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) analysis. Solubility and dissolution testing were conducted in phosphate buffer (pH 6.8). The results showed that the 1:2 ratio formulation yielded the most significant improvement, with solubility reaching 22.3 mg/mL and a dissolution rate of 97.6% within 30 minutes, representing a substantial enhancement compared to pure caffeine. FTIR and DSC indicated the presence of hydrogen bonding and the absence of caffeine melting peak, while PXRD confirmed amorphization. These findings suggest that solid dispersion with PVP K-30 is a viable strategy for overcoming the bioavailability challenges of caffeine and similar compounds, warranting further investigation into in vivo performance and long-term stability.
Co-Authors Bertha Rusdi Efrida, Delfiana Aura Fetri Lestari Fetri Lestari Hilda Aprilia, Hilda Indra Indra Kiki Mulkiya Yuliawati Mulkiya, Kiki Nabilla, Qori Rian Andrianto Sadiyah, Esti Rachmawati Sani Ega Priani Setianty, Tia Nur Somantri, Sri Yulianingsih Sri Peni Fitrianingsih Syafnir, Livia Umi Yuniarni Yani Lukmayani