Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Nur Aini
Fakultas Farmasi, Universitas Islam Kalimantan Muhammad Arsyad Al-Banjari
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
KAJIAN SUHU REAKSI TERHADAP POLA SUBSTITUSI DAN HASIL SINTESIS DERIVAT KUERSETIN Nur Aini; Muhammad Fauzi; Nily Su’aida
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2976

Abstract

Quercetin is a flavonoid compound with various pharmacological activities but has limited solubility and stability. The derivatization synthesis of quercetin through acylation with benzoyl chloride was carried out at temperatures of 25°C, 40°C, and 60°C using acetone as the solvent and pyridine as the catalyst. The reflux reaction for 12 hours produced mono-benzoylation characterized by Thin Layer Chromatography (TLC), column chromatography, as well as UV-Vis and IR spectra confirming the presence of benzoyl groups on quercetin. The 60°C temperature resulted in multi-benzoylation substitution, indicated by two carbonyl bands at 1785.00 cm⁻¹ and 1742.36 cm⁻¹, along with the highest yield of 88%. Controlling the reaction temperature can direct a more selective substitution pattern and improve the efficiency of quercetin derivatization. Higher temperatures accelerate the reaction rate and promote multi-substitution, potentially affecting the biological activity of the product.
Co-Authors Muhammad Fauzi Nily Su’aida