ABSTRAK Latar Belakang: Kualitas hidup menggambarkan sejauh mana pasien diabetes melitus menilai kondisi mereka secara positif atau negatif mengenai penyakit mereka. Penurunan kualitas hidup pada individu dengan diabetes melitus sering berkaitan dengan kurangnya kemampuan pasien untuk melakukan perawatan diri secara mandiri. Ketidakmampuan ini dapat berdampak pada berbagai aspek kehidupan, seperti kondisi fisik, kesejahteraan mental, interaksi sosial, dan hubungan dengan lingkungan sekitar (Chaidir et al., 2017). Tujuan: Untuk mengetahui hubungan self care management dengan kualitas hidup pada pasien diabetes melitus di wilayah kerja Puskesmas Singandaru di Serang. Metode: Penelitian ini merupakan penelitian analitik korelasional dengan pendekatan cross-sectional. Teknik pengambilan sampel yang digunakan adalah non probability sampling, dengan jumlah responden sebanyak 48 orang. Responden mengisi kuesioner yang telah disiapkan. Analisis data menggunakan uji Chi-Square. Hasil: Mayoritas tingkat self care management dan kualitas pasien diabetes melitus di wilayah Puskesmas Singandaru Serang adalah baik, sejumlah 16 orang. Nilai Odds Ratio (OR) sebesat 2,364 dan rentang confidence interval 95% (0,735– 7,603). Kesimpulan: Tidak terdapat hubungan self care management dengan kualitas hidup pasien diabetes melitus di wilayah kerja Puskesmas Singandaru Serang (p value 0,146). Kata Kunci: Diabetes melitus, kualitas hidup, Self care management ABSTRACT Background: Quality of life describes the extent to which patients with diabetes mellitus assess their condition positively or negatively regarding their disease. Decreased quality of life in individuals with diabetes mellitus is often related to the patient's lack of ability to perform self-care independently. This inability can impact various aspects of life, such as physical condition, mental well-being, social interactions, and relationships with the surrounding environment (Chaidir et al., 2017). Objective: To determine the relationship between self-care management and quality of life in diabetes mellitus patients at the Singandaru Community Health Center in Serang. Method: This study was a correlational analytical study with a cross-sectional approach. The sampling technique used was non-probability sampling, involving a total of 48 respondents. Respondents completed a structured questionnaire. Data analysis was conducted using the Chi-Square test. Results: The majority of diabetes mellitus patients at the Singandaru Community Health Center in Serang had good self-care management and good quality of life, totaling 16 respondents. The Odds Ratio (OR) was 2.364, with a 95% confidence interval of 0.735–7.603. Conclusion: There was no significant relationship between self-care management and quality of life among diabetes mellitus patients in the Singandaru Community Health Center area (p-value = 0.146). Keywords: Diabetes mellitus, self care management, quality of life