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All Journal Indonesian Journal of Biomedicine and Clinical Sciences Jurnal Penelitian Keperawatan
Loury Priskila
Fakultas Kedokteran Universitas Kristen Duta Wacana Yogyakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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PERBANDINGAN NILAI INDEKS CASTELLI RISK II PADA FAKTOR RESIKO STROKE ISKEMIK SERANGAN PERTAMA Zenine Charolin Sinulingga; Rizaldy Taslim Pinzon; Loury Priskila; MMA Dewi Lestari
Jurnal Penelitian Keperawatan Vol 12 No 1 (2026): Jurnal Penelitian Keperawatan
Publisher : STIKES RS Baptis Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32660/jpk.v12i1.925

Abstract

Background: Ischemic stroke is the most common type of stroke and a leading cause of disability and death. One of its major risk factors is dyslipidemia, which can be assessed using the Castelli Risk Index II (CRI-II), calculated as the ratio of LDL to HDL. A high CRI-II indicates increased atherogenic potential and a higher likelihood of stroke occurrence, particularly the first event. Objective: This study aims to determine the comparison of CRI-II values based on ischemic stroke risk factors such as hypertension, age, sex, diabetes mellitus, smoking status, and lipid profiles in patients with first-onset ischemic stroke. Methods: This was a descriptive analytic study using a cross-sectional approach and secondary data from 120 ischemic stroke patients aged 40–59 years across several hospitals in Yogyakarta. Data analysis was conducted using the Kolmogorov-Smirnov normality test and the chi-square test to assess relationships between variables. Results: Most patients (55%) had high CRI-II values (>3.5). No significant differences in CRI-II were found based on hypertension, age, sex, smoking status, or history of diabetes mellitus. However, there was a significant association between high LDL levels and CRI-II values (p=0.001), indicating the dominant role of LDL in increasing atherosclerotic risk, as LDL is directly involved in the CRI-II calculation. Conclusion: There were no significant differences in CRI-II values across most analyzed risk factors, except for LDL levels. This highlights the importance of lipid control, especially LDL, in preventing first-time ischemic stroke.
A case of invasive ductal and lobular carcinoma in man with current treatment and palliative approach Leonardo Cahyo Nugroho; Ida Ayu Triastuti; Loury Priskila
Indonesian Journal of Biomedicine and Clinical Sciences Vol 58 No 4 (2026): in press
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v58i4.26689

Abstract

Male breast cancer accounts for less than 1% of all breast malignancies, yet its incidence has been rising in recent years. Because clinicians rarely suspect the diagnosis in men, presentation is frequently delayed and outcomes tend to be worse than in women. We report a case illustrating how this delay can unfold in practice, along with the multidisciplinary approach required once advanced disease is confirmed. A 62-year-old man presented with a one-year history of a right breast mass that had progressed to a chronic, ulcerated wound with yellowish discharge and intermittent bleeding. Breast ultrasonography identified the lesion as BI-RADS 5. Additionally, a chest radiograph indicated possible pulmonary metastasis. Histopathology confirmed invasive ductal carcinoma, non-special type, with invasive lobular differentiation grade III and nuclear pleomorphism grade II. The case highlights two recurring problems in male breast cancer: patients and primary-care providers alike tend to attribute early symptoms to benign causes, and formal screening pathways for men simply do not exist. By the time malignancy is confirmed, disease is often locally advanced or metastatic, as seen here. Management therefore had to combine palliative wide excision for local symptom control with systemic therapy guided by receptor status. Although rare, male breast cancer warrants the same clinical vigilance given to female patients presenting with a breast lump. Earlier recognition, paired with individualized and multidisciplinary treatment, including palliative care where indicated, remains the most realistic route to better outcomes.
Co-Authors Ida Ayu Triastuti Leonardo Cahyo Nugroho MMA Dewi Lestari Rizaldy Taslim Pinzon Zenine Charolin Sinulingga