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All Journal Jurnal Kedokteran Brawijaya Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Jurnal Sosial dan Sains The Journal of Society Medicine (JSOCMED) Cermin Dunia Kedokteran
Fitri, Fasihah Irfani
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Astronomy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Physics Public Health

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Cognitive Function Characteristics in Patients with Myasthenia Gravis Khairina, Yunika; Fitri, Aida; Fitri, Fasihah Irfani
Journal of Society Medicine Vol. 2 No. 6 (2023): June
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i6.52

Abstract

Introduction: Myasthenia gravis (MG) is one of the most common neuromuscular junction disorders with various clinical presentations. Several studies showed cognitive function decline in MG patients which affects cognitive domains in memory, attention, executive function, and verbal. The involvement of the central cholinergic system, known as central cholinergic deficits are thought to manifests as impaired cognitive function in patients with MG. The purpose of this study was to evaluate cognitive function characteristic in patients with myasthenia gravis. Method: This study used a cross-sectional design, involved 33 myasthenia gravis patients in Neurology Outpatient Clinic of Haji Adam Malik Central General Hospital and 33 subjects in healthy control group. Cognitive function tests were performed using the Indonesia version of Montreal Cognitive Assessment (MoCA-Ina). Mann-whitney test was performed to evaluate cognitive performance difference in both groups. Results: : The results were compared between MG and healthy control group. The mean of MoCA-Ina score was significantly lower in MG group compared to healthy control group. The result of this study showed difference in cognitive performance between MG patients and healthy control group (p<0.001). This study showed delayed memory, attention, verbal, abstraction, visuospatial and executive function performance was decline in MG patients. Conclusion: This study concludes significant difference of cognitive performance based on MoCA-Ina scores between myasthenia gravis patients and healthy control group.
Relationship between Homeostatic Model Assessment for Insulin Resistance and Waist Hip Ratio with Cognitive Function in Type 2 Diabetes Mellitus Fitri, Fasihah Irfani; Novita, Oriza; Hutagalung, Haflin Soraya
Journal of Society Medicine Vol. 2 No. 7 (2023): July
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i7.60

Abstract

Introduction: Cognitive impairment is a common complication of Type 2 Diabetes Mellitus (T2DM) in which the underlying mechanism are insulin resistance and associated central obesity. Homeostatic model assessment of insulin resistance (HOMA-IR) and waist-hip ratio (WHR) have been used as markers for insulin resistance and central obesity, respectively, but their direct association with cognition remains unclear. This study was conducted to determine the relationship between HOMA-IR and WHR with cognitive function in T2DM patients. Method: This was a correlative analytic study with a cross sectional design involving T2DM pateints. The HOMA-IR was assessed based on blood laboratory results, the WHR was measured by dividing circumference of the waist by the circumference of the hips and cognitive function was assessed using the Montreal Cognitive Assessment Indonesian Version (MoCA-INA). Results: : There were 56 patients included in the study. There was no significant relationship between HOMA-IR and cognitive function in T2DM patients (p=0.276; r=0.148). There was also no significant relationship between WHR and cognitive function (p = 0.499; r = 0.092). Conclusion: The HOMA-IR and WHR were not correlated with cognitive function in T2DM.
Correlation between IgG Anti-Toxoplasmosis Gondii Antibodies and Cognitive Function in Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS) Patients with Cerebral Toxoplasmosis Puspitasari, Carina Shelia; Fitri, Fasihah Irfani; Ritarwan, Kiking
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 3 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i3.12049

Abstract

Background: Patients with HIV-AIDS are at increased risk for both opportunistic infections, such as cerebral toxoplasmosis, and cognitive impairment. IgG anti-Toxoplasmosis gondii (T.gondii) is a marker for latent infection. However, its role in cognition in HIV patients remains unclear. The study aims to determine the correlation between Ig-G anti-T.gondii and each domain cognitive function in HIV patients with cerebral toxoplasmosis. Method: This was a cross-sectional study involving 110 HIV patients with cerebral toxoplasmosis who met the inclusion and exclusion criteria. We assessed cognitive function using Montreal Cognitive Assessment Indonesian Version (MoCA-INA) and measured the IgG anti-T.Gondii using the ELISA method. The Spearman correlation test was used to determine the correlation between Ig-G anti-T.gondii with each cognitive domain. Results: There was a significant correlation between IgG anti-T.gondii and cognitive function. (p = 0.004, r = -0.275). There was also significant relation between IgG anti-T.gondii with attention (p = 0.046, r =-0.19), abstraction (p = 0.036, r = -0.2), and delayed recall (p = 0.047, r =-0.19). But there was no significant relation between Ig-G anti-T.gondii with visuospatial (p = 0.171), naming (p = 0.521), language (p = 0.810), and orientation (p = 0.11) Conclusion: Lower Level Of IgG Anti-Toxoplasmosis Gondii Antibodies Is Associated With Worse Cognitive Function In Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS) Patients with Cerebral Toxoplasmosis
Hubungan antara Risiko Jatuh dengan Kualitas Hidup pada Lanjut Usia di Unit Pelaksana Teknis Daerah Pelayanan Sosial Lanjut Usia Binjai Umry, Sofwan Hadi; Iqbal, Kiki M.; Fitri, Fasihah Irfani
Jurnal sosial dan sains Vol. 5 No. 4 (2025): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v5i4.32153

Abstract

Kemampuan seseorang untuk melakukan aktivitas sehari-hari atau status fungsional akan menurun seiring bertambahnya usia. Penurunan ini dapat menyebabkan lansia mengalami imobilisasi, yang mengakibatkan ketergantungan pada orang lain dan meningkatkan potensi terjadinya jatuh. Penelitian ini bertujuan untuk menilai hubungan antara risiko jatuh menggunakan instrumen Berg Balance Scale (BBS) dengan kualitas hidup pada lansia. Penelitian ini menggunakan desain analitik dengan metode cross-sectional tanpa adanya perlakuan, dengan sumber data primer dari 36 lansia yang memenuhi syarat penelitian (kriteria inklusi dan eksklusi) dan memberikan persetujuan tertulis, yang diambil dari seluruh pasien lansia di unit pelaksana teknis daerah pelayanan sosial lanjut usia Binjai. Penilaian risiko jatuh dengan menggunakan instrumen Berg Balance Scale (BBS) sedangkan kualitas hidup dinilai menggunakan kuisioner SF-36. Mayoritas subjek penelitian adalah Perempuan sebanyak 21 orang (58,3%), berada pada rata-rata usia 62,8 tahun, kejadian jatuh sebanyak 9 orang (25 %). Dalam pemeriksaan keseimbangan menggunakan instrumen Berg Balance Scale (BBS)) menunjukkan bahwa mayoritas responden (72,2%) memiliki risiko jatuh rendah. Kualitas hidup yang diukur menggunakan SF-36 menunjukkan bahwa 97,2% responden memiliki kualitas hidup yang baik. Secara keseluruhan, mayoritas responden memiliki risiko jatuh yang rendah dan kualitas hidup yang tinggi. Hasil analisa statistik menunjukkan adanya hubungan yang signifikan antara Berg Balance Scale (BBS) dengan kualitas hidup lansia yang dinilai dengan menggunakan kuisioner SF-36 (p = 0,001). Terdapat hubungan antara Berg Balance Scale (BBS) dengan kualitas hidup lansia.
Correlation between Atherogenic Index of Plasma and Various Domains of Cognitive Function in Type 2 Diabetes Mellitus Patients Fitri, Fasihah Irfani; Simanjuntak, Pahala
Jurnal Kedokteran Brawijaya Vol. 32 No. 3 (2023)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.03.6

Abstract

Cognitive impairment in patients with Type 2 Diabetes Mellitus (T2DM) is related to the lack of blood supply to the brain. Previous studies showed that the atherogenic index of plasma (AIP) is a predictor of vascular abnormalities, but studies investigating its association with cognitive functions in T2DM patients younger than 60 years remain limited. This study aimed to determine the correlation between AIP and various domains of cognitive function in T2DM patients. This study was a cross-sectional study involving 75 T2DM patients selected using a consecutive sampling technique at Haji Adam Malik General Hospital Medan from July 2021 to January 2022. Cognitive function was examined using the Visual Cognitive Assessment Test Indonesian Version (VCAT-INA) on several cognition domains. The AIP value of each patient was measured and categorized into high (AIP>0.21), intermediate (AIP between >0.11 and ≤0.21), or low (≤0.11). The mean triglyceride level was 176±108.3mg/dl, the HDL-C level was 38.3±12.1mg/dl, and the mean AIP value was 0.191±0.25. The mean score of the VCAT-INA was 21.7±2.3, which was lower than normal. The AIP value showed significant negative correlation with global cognition (r=0.432, p<0.001) and various cognitive domains, namely memory (r=-0.375, p=0.001), attention (r=-0.383, p=0.001), executive function (r=-0.051, p=0.663), visuospatial (r=-0.306, p=0.008), and language (r=-0.352, p=0.002). In short, there is a significant correlation between AIP value and domains of cognitive function, such as memory, attention, visuospatial, and language domains, but not with executive domains.
Correlation of Serum Malondialdehyde with Motor Severity and Cognitive Function in Parkinson’s Disease: Research Panggabean, Martinova Sari; Hutagalung, Haflin Soraya; Fitri, Fasihah Irfani
Cermin Dunia Kedokteran Vol 53 No 09 (2026): September 2026 - CDK 356
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i09.2326

Abstract

Introduction: Accumulating research supports the view that oxidative stress is a key driver of the pathological processes underlying Parkinson’s disease (PD). Among biomarkers of oxidative injury, malondialdehyde (MDA)—a key lipid peroxidation product—is frequently utilized to quantify oxidative stress; however, its relationship with motor symptom severity and cognitive function in PD remains insufficiently explored. This study aimed to examine the association between serum MDA levels, motor symptom severity, and cognitive function in patients with Parkinson’s disease. Methods: This cross-sectional study included 35 patients diagnosed with PD. Motor severity was assessed using the Unified Parkinson’s Disease Rating Scale Part III (UPDRS-III) and stratified into mild, moderate, and severe levels. Cognitive assessment utilized the Montreal Cognitive Assessment–Indonesia (MoCA-Ina) alongside trail making test part A (TMT-A) and trail making test part B (TMT-B). Serum MDA concentrations were measured using the thiobarbituric acid reactive substances (TBARS) assay. Statistical assessment was conducted using Spearman’s rank correlation alongside the Mann–Whitney U test. Results: This study revealed a meaningful positive linkage between MDA concentrations and motor symptom severity (r = 0.421, p = 0.012). Posthoc analysis indicated that patients with moderate and severe motor symptoms had higher MDA levels than those with mild symptoms (p = 0.032; p = 0.022), while no discrepancy was found between the moderate and severe groups (p = 0.421). MDA levels showed no significant association with MoCA-Ina or TMT-A performance (r = 0.206, p = 0.235; r = 0.079, p = 0.684), but patients with abnormal TMT-B performance had higher MDA levels than participants with normal results (p = 0.043). Conclusion: MDA level is linked to greater motor symptom severity and executive dysfunction in PD. The results imply that MDA may act as a promising biomarker reflecting oxidative damage–driven neurodegeneration underlying motor and executive impairments in PD.
Co-Authors Fitri, Aida Hutagalung, Haflin Soraya Iqbal, Kiki M. Khairina, Yunika Kiking Ritarwan Novita, Oriza Pahala Simanjuntak Panggabean, Martinova Sari Puspitasari, Carina Shelia Umry, Sofwan Hadi