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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Cermin Dunia Kedokteran
Dewi, Ade Yasinta
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Humanities Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Social Sciences Other

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Interleukin-6 (IL-6) dan Jalur NF-ΚB Target Kunci Inflamasi dalam Proses Penuaan Dewi, Ade Yasinta; Dewi, Ni Nyoman Ayu
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i11.62478

Abstract

Aging is a complex biological process characterized by a gradual decline in physiological functions and increased susceptibility to degenerative diseases. A hallmark of aging is low-grade, chronic, non-infectious inflammation known as inflammaging. This phenomenon is driven by the accumulation of senescent cells that actively secrete pro-inflammatory mediators through the senescence-associated secretory phenotype (SASP). Among these mediators, Interleukin-6 (IL-6) and the transcription factor Nuclear Factor-kappa B (NF-κB) play central roles. NF-κB acts as a master regulator of pro-inflammatory gene expression, including IL-6, and is activated by various stimuli such as oxidative stress and DNA damage. IL-6 secreted by senescent cells activates the JAK/STAT3 pathway, which in turn enhances NF-κB activity, creating a positive feedback loop that sustains chronic inflammation. This mutual reinforcement between IL-6/STAT3 and NF-κB signaling drives progressive tissue damage, impairs regeneration, and increases the risk of age-related diseases such as atherosclerosis, diabetes, osteoarthritis, and neurodegenerative disorders. This review discusses the roles of IL-6 and NF-κB in the mechanisms of inflammaging and evaluates their potential as therapeutic targets to slow aging and prevent age-associated diseases.
Aktivitas Fisik Rutin sebagai Anti-Aging dan Pencegahan Sarkopenia pada Wanita: Tinjauan Pustaka Dewi, Ade Yasinta; Ayu Dewi, Ni Nyoman
Cermin Dunia Kedokteran Vol 53 No 01 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i01.1982

Abstract

Aging is a natural process of declining body functions, including a decrease in muscle mass and strength known as sarcopenia. Sarcopenia has a higher prevalence in menopausal women due to the decline in estrogen levels. This condition affects quality of life, fall risk, and independence. This literature review explores the role of regular physical activity as an anti-aging intervention and prevention of sarcopenia in women. A literature search was conducted in the Google Scholar, PubMed, ScienceDirect, and DOAJ databases for relevant articles (originalresearch or reviews) published between 2024 and 2025. Data analysis used a narrative synthesis approach on 30 selected articles. Results showed that consistently performed physical activity, especially resistance training (moderate–high intensity), multimodal training, andtraining with blood flow restriction, is highly effective in improving muscle mass, strength, and physical function. Combination of physical activity with adequate protein intake (≥ 1.0 g/kgBB/day) showed significant synergistic effects, especially in women with sarcopenic obesity.Technology-based interventions potentially improve program adherence. It is concluded that regular physical activity, particularly resistance training supported by optimal nutrition, is an effective non-pharmacological strategy to slow the aging process and prevent sarcopenia.
Co-Authors Ayu Dewi, Ni Nyoman Ni Nyoman Ayu Dewi