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All Journal Pharmademica: Jurnal Kefarmasian dan Gizi JURNAL JAMU KUSUMA Journal of Local Therapy
Nasikin, M. Ali
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PHYSICAL QUALITY EVALUATION AND ANTIOXIDANT ACTIVITY OF RED WATERMELON (Citrullus lanatus Thunb.) RIND EXTRACT LOTION Purwasih, Ratih; Nasikin, M. Ali
Jurnal Jamu Kusuma Vol. 3 No. 2 (2023): JURNAL JAMU KUSUMA
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jurnaljamukusuma.v3i2.69

Abstract

Skin is an organ that covers the entire surface of a living creatures’s body. The topical preparations such as lotions is widely used to protect the skin from free radicals because the antioxidant content. One of plant that can be used is watermelon. Red watermelon rind contains lycopene, vitamin C, niacin, citrulline, beta-carotene, and vitamin E, which function as antioxidants. The aim of this study was to determine the physical quality and antioxidant activity of red watermelon rind extract lotion (Citrullus lanatus Thunb.). This methods of research was a quantitative descriptive. The lotion was made in four formula with various concentration of extract including F0(0%), F1(5%), F2(10%), and F3(20%). The lotion was evaluated for physical quality and antioxidant activity using a UV-Vis spectrophotometer. Physical quality assay for lotions include organoleptic, homogeneity, spreadability, stickiness, pH, and viscosity assay. The result of organoleptic F0 was a white in color, semi-solid, and has a distinctive base smell. The F1-F3 lotion was brownish-white, semi-solid, and has a characteristic smell of watermelon rind. The lotions were homogeneous, with spreadibility of 5.23-6.35 cm, stickiness of 1.55-3.50 seconds, pH of 5.50-6.81, and viscosity of 2755-4351 cps. The lotion F0 was classified as very weak antioxidant activity with an IC50  of 577.59 ppm, F1-F2 were classified as the moderate antioxidant activity with IC50 of 141.91 ppm and 100.31 ppm, and F3 was a strong antioxidant activity with IC50 of 59.93 ppm. All lotion formulas have complied with the topical preparation reference and SNI-16-4399-1996.
QUALITY AND ANTIOXIDANT ACTIVITY TEST OF ALBEDO WATERMELON (Citrullus lanatus Tunb.) COMBINATION GUAVA FRUIT COMBINATION (Psidium guajava L.) Rusita, Youstiana Dwi; Nasikin, M. Ali; Agustin, Arum Dwi
Jurnal Jamu Kusuma Vol. 4 No. 2 (2024): JURNAL JAMU KUSUMA
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jurnaljamukusuma.v4i2.116

Abstract

Jam is a food product with a gel or semi-solid consistency that is spread on food made from processed fruits and sugar without the addition of other food ingredients and permitted food additives. This study created a formulation of jam preparations from the albedo of watermelon rind (Citrullus lanatus Tunb.) in combination with guava fruit (Psidium guajava L.) because they contain vitamin C, which has antioxidant activity. The purpose of this study was to determine the formulation and antioxidant activity of the albedo jam preparation of watermelon rind (Citrullus lanatus Tunb.) and guava fruit (Psidium guajava L.). This study used a quantitative descriptive method with observations of jam quality according to SNI 01-3746-2008. The test parameters were jam quality tests, including organoleptic, pH, water content, colour test, and antioxidant activity tests. The organoleptic results of the jam had a bright red colour with a distinctive aroma of watermelon and red guava and had a slightly sour, sweet taste. The results of the pH test of the jam on F1, F2, and F3 were respectively 3.72 ± 0.025, 3.84 ± 0.017, and 3.85 ± 0.032. The results of the water content test of the jam on F1, F2, and F3 were respectively 29.34 ± 0.464, 29.18 ± 0.375, and 28.71 ± 0.437. The results of the jam colour test showed positive vitamin C content. The IC50 values of the jam preparations on F1, F2 and F3 were respectively 155.345 ppm, 145.581 ppm, and 130.241 ppm. The F1 jam preparation is a weak antioxidant, while F2 and F3 are moderate antioxidants.
FORMULATION AND TESTING OF ANTIBACTERIAL ACTIVITY OF FACIAL TONER PREPARATIONS CHINESE BELT LEAF EXTRACT (Peperomia pellucida L. Kunth) AGAINST THE BACTERIA Propionibacterium acnes Nasikin, M. Ali; Ridlo, Achmad; Rakhmayanti, Regia Desty; Hapsari, Azizah Nur
Journal of Local Therapy Vol 3 No 2 (2024): Journal of Local Therapy
Publisher : Pusat Unggulan IPTEK Poltekkes Kemenkes Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/jlt.v3i2.4674

Abstract

Abstract: Chinese betel leaf (Peperomia pellucida L.Kunth) is a herbal plant that can be used to treat abscesses, acne, boils and skin inflammation. Chinese betel leaves contain chemical compounds including alkaloids, flavonoids, saponins, tannins and triterpenoids which can inhibit the growth of Propionibacterium acnes bacteria. The Chinese betel leaf extract content can be used as a refreshing toner, especially for dry and acne-prone skin. The aim of this research is to determine the results of physical quality tests and antibacterial activity of Chinese betel leaf extract facial toner formulations with an additional active ingredient concentration of 7.5%; 15% and 30%. This type of research is experimental research with a descriptive research design. The organoleptic test results of the base are clear and odorless, while the other 3 formulas are brownish green in color, have a distinctive aroma of Chinese betel leaf extract and are in liquid form. The homogeneity test results of the preparation are homogeneous. F0 pH test results 6.327; FI 5.344; FII 5,243 and FIII 5,067. Viscosity test results F0 5.32 cps FI 6.34 cps and FII 6.33 cps. The results of the antibacterial activity test F0, FI, FII, and FIII were respectively 0.00 mm, there was no inhibition zone, 7.37 mm, 13.35 mm, 16.24 mm and in the positive control clindamycin it was 21.17 mm. Based on the results of the physical quality test and antibacterial activity of the toner preparation, the toner preparation has met existing quality standards so it is safe to use and the toner preparation with the strongest antibacterial activity is found in FIII.
DETERMINATION OF PHENOL CONTENT AND PHYSICAL TEST OF COMBINED JAMU POWDERRED GINGER (Zingiber officinale Rosc. var. rubrum), KENCUR (Kaempferia galanga L.) AND TURMERIC (Curcuma domestica Val.) Rusita, Youstiana Dwi; Ridlo, Achmad; Nasikin, M. Ali; Wijayanti, Ayu Rizki
Journal of Local Therapy Vol 3 No 2 (2024): Journal of Local Therapy
Publisher : Pusat Unggulan IPTEK Poltekkes Kemenkes Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/jlt.v3i2.4673

Abstract

Abstract: Powdered herbs are in the form of fine grains ground from sifted simplicia, blended with different compositions adjusted to the function and benefits of the herb, powdered herbs are consumed by brewing with warm water. This study was to determine the organoleptic physique, pH, moisture content, weight uniformity, and phenol content of herbal medicine powder in combination with red ginger (Zingiber officinale Rosc. var. rubrum), kencur (Kaempferia galanga L.) and turmeric (Curcuma domestica Val.). The method used to measure pH was using a pH meter, the moisture content using the gravimetric method, the phenol level using the foline ciocalteau method with the standard standard of gallic acid. The organoleptic results of herbal powder are in the form of powder, the taste in composition 1 is a bit bitter, in composition 2 the typical bitterness of turmeric is a little spicy, and in composition 3 it is a bit bitter. The pH results of composition 1, 2 and 3 were 5.954, 6.088 and 6.105. The results of the moisture content of composition 1, 2 and 3 were 8.1639, 6.8732 and 8.1042 respectively. The result of the uniformity of the weight of the second composition is 15% red ginger, 40% kencur, 45% turmeric.
Analisa Kandungan Formaldehid Pada Sediaan Cat Kuku (Kutek) yang Diperjualbelikan di Pasar Kota Wonogiri Andriastuti, Deitra Aprilia; Nasikin, M. Ali; Rakhmayanti, Regia Desty
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 1 (2024): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i1.61

Abstract

Nail polish is a pigment that is deposited in a volatile solvent to cover the natural color of the nail and as an attractiveness enhancer that uses formaldehyde. Formaldehyde (H2CO) with the trade name formalin solution, which functions as a nail polish hardener, so that the nail polish is more adhesive and thicker. This study aims to determine whether nail polish preparations traded in the Wonogiri city market contain formaldehyde with levels that exceed the limit according to the Regulation of the Head of the Food and Drug Supervisory Agency of the Republic of Indonesia Number 18 of 2015, which is <5%. Qualitative analysis used resorcinol reagent, while quantitative analysis used UV-Vis spectrophotometry at a wavelength of 550 nm. The sample used in this study was nail polish taken from the market in Wonogiri, 9 samples with sample codes A, B, C, D, E, F, G, H, and I. The results showed that 9 samples of nail polish studied meet the requirements of the level limit of less than 5%, with the largest level obtained at 3.349% for the code I sample and the smallest level at 0.750% for the code E sample. Keywords: nail polish, formaldehyde, UV-Vis spectrophotometry  
Analisis Kandungan Hidrokuinon pada Hand Body Lotion yang Dijual di Kecamatan Klaten Tengah dengan Metode Spektrofotometri Uv Vis Ningrum, Ayu Dwi Retno; Rakhmayanti, Regia Desty; Nasikin, M. Ali
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 2 (2025): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i2.66

Abstract

Hydroquinone is a compound used as a whitening agent and to prevent pigmentation. The use of hydroquinone in hand body lotion is prohibited by BPOM because it can cause skin irritation, redness, burning sensation, bluish or blackish skin (ochronosis), cancer. This study aims to identify the content and determine the levels of hydroquinone in hand body lotion sold in Klaten Tengah District using the UV-Vis spectrophotometry method. The research method used is quantitative descriptive. The samples obtained were eight and were coded A, B, C, D, E, F, G, and H. The results showed that all samples were positive for hydroquinone with levels of 2.54%; 0.20%; 0.14%; 0.17%; 0.30%; 1.25%; 0.37%; and 2.10% so that they do not meet the requirements of BPOM RI No.23 of 2019.  
Co-Authors Achmad Ridlo Agustin, Arum Dwi Andriastuti, Deitra Aprilia Hapsari, Azizah Nur Ningrum, Ayu Dwi Retno Rakhmayanti, Regia Desty Wijayanti, Ayu Rizki Youstiana Dwi Rusita, Youstiana Dwi