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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Fajar Wasilah
Department of Clinical Pathology, Faculty of Medicine, Universitas Padjadjaran – Hasan Sadikin Hospital, Bandung, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Diagnostic Performance of Fecal pks+ Escherichia coli for Detecting Neoplastic Colorectal Lesions in Suspected Colorectal Cancer Patients Anton Sumarpo; Ida Parwati; Fajar Wasilah; Didik Setyo Heriyanto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 3 (2026)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i3.2894

Abstract

Genotoxin-producing pks+ Escherichia coli is implicated in the pathogenesis of colorectal cancer (CRC). This study was designed to evaluate the diagnostic performance of fecal pks+ E. coli as a non-invasive biomarker for CRC screening. In this cross-sectional study, fecal samples from 70 patients with suspected CRC were analyzed by quantitative polymerase chain reaction (qPCR) to detect the presence of pks+ E. coli. The diagnostic accuracy was assessed against colonoscopy and histopathology findings. Against histopathology as the gold standard, fecal pks+ E. coli detected neoplastic lesions with a sensitivity of 70.59% and a specificity of 65.22%. Notably, the relative gene copy number of pks+ E. coli was significantly higher in patients with neoplastic lesions compared to those with non-neoplastic findings. Fecal testing for pks+ E. coli demonstrates potential as a non-invasive biomarker for detecting neoplastic colorectal lesions, though further validations are needed.
Co-Authors Anton Sumarpo Didik Setyo Heriyanto Ida Parwati