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All Journal Biology, Medicine, & Natural Product Chemistry Sehat Rakyat: Jurnal Kesehatan Masyarakat
Edwin Hadinata
Universitas Ciputra
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Eksplorasi Faktor Risiko Penyakit Kardiovaskular dan Hubungannya dengan Kejadian Hipertensi pada Guru Biologi di Gorontalo Antonius Yansen Suryadarma; Nathania Disa Ariesta Andriani; Minarni Wartiningsih; Cempaka Harsa Sekarputri; Edwin Hadinata
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 5 No. 3 (2026): Agustus 2026
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v5i3.8487

Abstract

Background: Cardiovascular disease (CVD) remains the foremost cause of mortality worldwide, with hypertension being the most important modifiable risk factor. Although teachers play an important role in health education, evidence on CVD risk factors among teachers, particularly biology teachers, remains limited. This study aimed to describe CVD risk factors and explore their association with hypertension among biology teachers in Gorontalo. Methods: A cross-sectional study was conducted among 39 members of the Musyawarah Guru Mata Pelajaran (MGMP) biology teacher in Gorontalo City. Data were collected through questionnaires and physical examinations. Association between categorical variables were analyzed using the Chi-square / Fisher's exact test, along with odds ratios (OR) and 95% confidence intervals (CI). Results: Most participants were female (87.2%) and aged ≥40 years (66.7%). The prevalence of hypertension, overweight/obesity, and central obesity was 59.0%, 61.5%, and 71.8%, respectively. Insufficient physical activity was identified in 43.6% of participants, while daily consumption of sweet foods, sugar-sweetened beverages, and monosodium glutamate (MSG) seasonings remained common. Bivariate analyses showed no significant association between investigated risk factors and hypertension. However, a higher risk of hypertension was observed among those aged ≥40 years (OR = 3.60; 95% CI: 0.73–18.41) and those with mental health problems, although the associations were not statistically significant. Conclusion: Biology teachers in Gorontalo had a high burden of CVD risk factors, particularly hypertension, overweight/obesity, central obesity, and unhealthy dietary habits. These findings support strengthening health promotion, routine screening, and implementing the GERMAS and CERDIK programs in schools to prevent CVD.
Correlations Between Anti-SARS-CoV-2 Titers, CD4+ T-Cell Counts, and COVID-19 Severity Edwin Hadinata; Eko Surachmanto; Paul N. Harijanto
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.1549-1553

Abstract

Coronavirus disease 2019 (COVID-19) presents with diverse symptoms ranging from mild to severe. Patients with severe COVID-19 can show impaired humoral and cellular immunity and excessive pro-inflammatory cytokine production. Antibodies are generated against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) due to the activation of the humoral immune system. Molecular-based testing is currently used to diagnose COVID-19. Determining antibody and CD4+ T cell counts can help monitor the antibody response to assess the risk of reinfection and vaccine response. This study aimed to determine the relationships between Aanti-SARS-CoV-2 titer, CD4+ T cell count, and COVID-19 severity. This analytic observational study used a cross-sectional design with consecutive sampling and was conducted at RSUP Prof. Dr. R. D. Kandou Manado Hospital from April to October 2021. It comprised 48 patients with COVID-19. The data were compared using Spearman’s rank correlation coefficient (rs). Anti-SARS-CoV-2 titers were nonsignificantly correlated with COVID-19 severity (rs = 0.081, p = 0.582) and CD4+ T cell counts (rs = 0.214, p = 0.145). In contrast, CD4+ T cell counts were significantly negatively correlated with COVID-19 severity (rs = -0.454, p = 0.001). Anti-SARS-Cov-2 titers cannot be used as an indicator of COVID-19 severity. Moreover, CD4+ T cell counts cannot be used as a marker of anti-SARS-CoV-2 titers. However, COVID-19 severity correlates negatively with CD4+ T cell counts, indicating that CD4+ T cell counts can be used as an indicator of COVID-19 severity.
Co-Authors Antonius Yansen Suryadarma Cempaka Harsa Sekarputri Eko Surachmanto Minarni Wartiningsih Nathania Disa Ariesta Andriani Paul N. Harijanto