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Analisis Ekspresi BRAF dan TERT pada Kasus Papillary Thyroid Carcinoma Berdasarkan Stratifikasi Risiko ATA Cempaka Harsa Sekarputri,; Etty Hary Kusumastuti,; Gondo Mastutik
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundPapillary thyroid carcinoma (PTC) is the most common malignancy in thyroid, accounting for more than 80% of all thyroid cancer.Rrecurrences of the disease reach 30% cases. It has been widely observed that BRAF and TERT is associated with aggressivenessbehaviors in human cancer. Both are involved in the pathogenesis of PTC that may be used as targets for new therapies. AmericanThyroid Association (ATA) risk stratification can define the risk of recurrence in PTC. No marker has been found to determine therisk of PTC recurrence. The purpose of this study is to analyzed BRAF and TERT expression in ATA risk stratification system inPTC classic variant samples.MethodsThe methods of this study is an analytical observational study with cross sectional approach, conducted on 56 samples of PTCclassic variant selected from Department of Anatomical Pathology Dr. Soetomo General Hospital between January 2015-December2017 by determined criteria in ATA risk stratification groups of low risk, intermediate risk and high risk. The expression BRAF andTERT observed using immunohistochemical staining of Santa Cruz monoclonal antibody.ResultsThe result for each group based on ATA risk stratification groups of low risk were 13 samples (23.20%), intermediate risk were 25samples (44.62%) and high risk were 18 samples (32.12%).The correlation was assessed with Spearman’s rho correlation test. There is significant correlation BRAF (p=0.004) with a value ofr=0.374 and TERT(p=0.032) with a value of r=0.287 for ATA risk stratification.ConclusionBRAF and TERT expression showed significant correlation to ATA risk stratification in classic variant PTC.

Kasus Toksoplasmosis Serebri Tak Terduga dengan Gambaran Radiologi yang Menyerupai Keganasan Cempaka Harsa Sekarputri; Anisia Indiralia; Roebijanti
Majalah Patologi Indonesia Vol 31 No 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

ABSTRACTToxoplasmosis was Toxoplasma Gondii infection. In HIV-infected patients, the prevalence of toxoplasma infectionranges was 3-97%. Diagnosis cerebral toxoplasmosis almost failed to recognized varians clinical and radiologicalfeatures on organism identifiied from brain biopsy which difficult to extract from alive patient. This case reportdiscussed cerebral toxoplasmosis of brain biopsy HIV positive patient which unknown status HIV patient, previously.A 52-year-old male patient came complained not only loss of apatit and dizzy two months ago, but also fainted.MSCT Scan with and without contrast showed right temporooccipital glioblastoma. Brain MRI showed a lesion on theright temporoparietal area with perifocal edema pressing on the right lateral ventricle. Microscopical feature showedglial tissue containing large areas of necrosis with karyorrhexis debris, PMN and mononuclear leucocyte infiltration,scaterred of tachyzoites and bradyzoites, no signs of malignancy. HIV serological examination was confirmed and thepatient's results were found to be anti-HIV reactive. Conclusion diagnosis as cerebral toxoplasmosis.

Efektivitas Edukasi Pencegahan Napza Oleh Mahasiswa Kedokteran Dalam Meningkatkan Pengetahuan Generasi Muda Terkait Napza Hanna Tabita Hasianna Silitonga; Minarni Wartiningsih; Etha Rambung; Cempaka Harsa Sekarputri
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 5, No 7 (2022): Volume 5 No 7 Juli 2022
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v5i7.5157

ABSTRAK Narkoba atau NAPZA merupakan tantangan serius bagi generasi muda Indonesia. Kurangnya pengetahuan akan obat-obatan berbahaya ini dan dampaknya yang serius baik dari segi kesehatan dan ancaman hukum dapat menjadi salah satu faktor penyalahgunaan narkoba di kalangan anak muda. Salah satu komunitas yang menaungi banyak anak muda adalah Pelayanan Kasih Anak Bangsa. Pengabdian masyarakat ini bertujuan untuk mengatasi masalah yang dihadapi oleh para anggota komunitas yaitu terbatasnya pengetahuan mitra tentang narkoba. Solusi dari permasalahan tersebut yang sudah disepakati dengan mitra adalah edukasi tentang narkoba, pemberian poster yang melibatkan mahasiswa kedokteran dalam menyampaikan materi terkait jenis narkoba, dampak narkoba dan pencegahan penyalahgunaan narkoba yang disampaikan kepada 30 orang peserta. Hasil pengabdian masyarakat menunjukkan terdapat perbedaan pengetahuan sebelum dan sesudah kegiatan (p=0,000). Sesudah mendapatkan materi dan tanya jawab, pengetahuan peserta terkait NAPZA semakin meningkat dari nilai rata-rata pre-test sebesar 70 menjadi nilai post-test dengan rata-rata 92,67. Hal ini menunjukkan edukasi yang dilakukan oleh mahasiswa kedokteran efektif untuk meningkatkan pengetahuan peserta. Saran kedepannya agar terdapat peran serta dari keluarga dan pemangku kebijakan lainnya untuk mencegah penyalahgunaan narkoba di kalangan generasi muda. Kata Kunci: Sosialisasi, Narkoba, Remaja, Pengetahuan, Pencegahan ABSTRACT Drugs abuse are a serious challenge for Indonesia's young generation. Lack of knowledge about these dangerous drugs and their serious effects both in terms of health and legal threats can be one of the factors of drug abuse among young people. One of the communities that serves many young people is Pelayanan Kasih Anak Bangsa. This community service aims to overcome the problems faced by community members, namely the limited knowledge of partners about drugs. The solutions to these problems that have been agreed with partners are education about drugs and giving posters. All activities will involve medical students in conveying material related to types of drugs, the impact of drugs and prevention of drug abuse which are delivered to 30 participants. The results of community service show that there are differences in knowledge before and after the activity (p=0,000). After receiving the material and asking questions, participants' knowledge about drugs increased from the average pre-test value of 70 to the average post-test value of 92.67 This shows that the education conducted by medical students is effective in increasing participants' knowledge. Suggestion for the future, participation of families and other policy makers is very important to prevent drug abuse among the younger generation. Keywords: Socialitation, Drugs, Adolescent, Knowledge, Prevention

Efektivitas Pasca Vaksinasi Hepatitis B di Kecamatan Pakal, Surabaya, Jawa Timur William Sayogo; Wira Widjaya Lindarto; Cempaka Harsa Sekarputri; Jemina Lewi Santoso; Stefani Nurhadi; Ferdinand Aprianto Tannus; Inez Purnomasari Prajitno
Gorontalo Journal of Public Health VOLUME 5 NOMOR 2, OKTOBER 2022
Publisher : Universitas Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32662/gjph.v5i2.2461

Hepatitis is an infectious disease that is still a concern today and is at risk of becoming a chronic condition with complications of liver function failure. Screening is carried out to determine the level of response of the body's defense system induced by the vaccine in the population of Pakal district, Surabaya. This study assesses the relationship between antibody status and protection status after vaccination. The study involved 78 people who are eligible to receive the vaccine. After receiving the vaccine, the antibody status is checked and the data obtained were statistically tested and tested for association using a contingency coefficient. From 78 hepatitis B vaccine recipients, 69 people (88,46%) are antibody reactive and 9 people (11.54%) with non-reactive antibody status. From the Chi Square test and the contingency coefficient test, it is shown that there is a relationship between antibody status and protection status (α<0.05; 95% CI). The hepatitis B vaccine provides protection against the risk of hepatitis B virus infection for residents of the Pakal district of Surabaya who have a high-risk lifestyle.

Kasus Toksoplasmosis Serebri Tak Terduga dengan Gambaran Radiologi yang Menyerupai Keganasan Cempaka Harsa Sekarputri; Anisia Indiralia; Roebijanti
Majalah Patologi Indonesia Vol. 31 No. 2 (2022): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i2.503

ABSTRACTToxoplasmosis was Toxoplasma Gondii infection. In HIV-infected patients, the prevalence of toxoplasma infectionranges was 3-97%. Diagnosis cerebral toxoplasmosis almost failed to recognized varians clinical and radiologicalfeatures on organism identifiied from brain biopsy which difficult to extract from alive patient. This case reportdiscussed cerebral toxoplasmosis of brain biopsy HIV positive patient which unknown status HIV patient, previously.A 52-year-old male patient came complained not only loss of apatit and dizzy two months ago, but also fainted.MSCT Scan with and without contrast showed right temporooccipital glioblastoma. Brain MRI showed a lesion on theright temporoparietal area with perifocal edema pressing on the right lateral ventricle. Microscopical feature showedglial tissue containing large areas of necrosis with karyorrhexis debris, PMN and mononuclear leucocyte infiltration,scaterred of tachyzoites and bradyzoites, no signs of malignancy. HIV serological examination was confirmed and thepatient's results were found to be anti-HIV reactive. Conclusion diagnosis as cerebral toxoplasmosis.

Characteristics of Nonunion Fractures in Patients with Antebrachial Fractures at dr. Mohamad Soewandhie General Hospital Surabaya 2021-2022: A Retrospective Study Tasya Monica; Bimo Sasono; Cempaka Harsa Sekarputri
Journal Orthopaedi and Traumatology Surabaya Vol. 13 No. 1 (2024): April 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v13i1.2024.17-23

Background: Nonunion, a complication of fracture healing, can lead to patient morbidity. Contributing factors include age, gender, fracture type, multiple fractures, infection, prolonged nonsteroidal anti-inflammatory drug (NSAID) use, smoking, nutritional status, and history of chronic disease. This study aims to determine the prevalence and characteristics of nonunion antebrachial fractures at dr. Mohamad Soewandhie General Hospital Surabaya. Methods: This retrospective descriptive study involved 111 patients. Data was gathered from medical records treated at dr. Mohamad Soewandhie General Hospital Surabaya for antebrachial fracture during 2021-2022. The study protocol obtained approvals from two local ethical committees. Data included demographics, fracture characteristics, fracture type, multiple fractures, infection, NSAID use, hypertension and diabetes history, smoking habits, and nutritional status by BMI calculation. Results: This study found a 24.3% prevalence of antebrachial nonunion fractures at dr. Mohamad Soewandhie General Hospital Surabaya in 2021-2022, mostly in males (66.7%) aged 17-25 years (22.2%). Nonunion in antebrachial fractures is marked by high rates in closed (92.6%) and single fractures (92.6%). Notably, infections (22.2%), smoking (7.4%), and hypertension history (7.4%) are common contributors. Despite ideal BMI in many cases (44.4%), nonunion still occurred. Conclusions: The study conducted at Dr. Mohamad Soewandhie General Hospital in Surabaya revealed a high prevalence of antebrachial nonunion fractures at 24.3%, particularly among young males. It was found that closed, single fractures were the most common type, with infections, smoking, and a history of hypertension being significant contributing factors. Interestingly, even individuals with an ideal BMI were still at risk for nonunion.

Kepuasan Antenatal Care terhadap Kunjungan Ulang Ibu Hamil Puskesmas Simomulyo Shalzabila, Tiara Cahya Novia; Wartiningsih, Minarni; Sekarputri, Cempaka Harsa
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 4 No. 3 (2024): Februari
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v4i3.187

Angka Kematian Ibu (AKI) dan Angka Kematian Neonatal (AKN) pada negara Indonesia masih tergolong tinggi. Pelayanan kesehatan yang berkualitas berpengaruh terhadap tingkat kepuasan ibu hamil dan berhubungan dengan kunjungan ulang ibu hamil untuk melakukan antenatal care. Puskesmas Simomulyo Surabaya khususnya Poli KIA menyediakan layanan kesehatan antenatal care yang wajib dilakukan minimal 4 kali selama masa kehamilan. Tujuan peneliti untuk mengetahui hubungan tingkat kepuasan ibu hamil pada antenatal care dan kunjungan ulang ibu hamil di Puskesmas Simomulyo Surabaya. Jenis penelitian ini menggunakan pengkajian analitik observasional dengan rancangan cross-sectional. Sampel sebanyak 62 orang sebagai responden adalah ibu hamil yang pernah melakukan antenatal care di Poli KIA Puskesmas Simomulyo Surabaya. Pengumpulan data menggunakan kuesioner dalam lembar kertas. Analisis yang dilakukan adalah univariat dan bivariat dengan uji Chi-Square. Hasil penelitian didapatkan jumlah terbanyak responden berumur 17-25 tahun (46,8%) dan tidak/belum bekerja 59.7%, sedangkan pendidikan SMA/sederajat 54.8%. Ibu hamil dengan kunjungan ulang lebih dari 1 kali sebesar 91,9%. Dimensi kualitas pelayanan sebagian besar menunjukkan hasil yang baik. Reliability puas (46,8%), responsiveness sangat puas (58,1%), assurance puas (46,8%), empathy puas (48,4%), dan tangible sangat puas (45,2%). Disarankan untuk menjaga tingkat kunjungan ulang ibu hamil di poli KIA Puskesmas Simomulyo Surabaya.

Pencegahan Sindrom Metabolik melalui Edukasi dan Pendampingan Mandiri kepada Komunitas GBI Diaspora Sejahtera Surabaya Imelda Ritunga; Jemima Lewi Santoso; Cempaka Harsa Sekarputri; Yahya Haryo Nugroho; Hernycane Sosilya; Johanes Tanzil; Mellyanawati; Elizabeth Sulastri Nugraheni; Nazwa Syahlimar Alkatiri; Shabila Ikha Pertiwi; Maynard Adam Liemdjaja
Jurnal Leverage, Engagement, Empowerment of Community (LeECOM) Vol. 6 No. 1 (2024): Jurnal Leverage, Engagement, Empowerment of Community (LeECOM)
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/leecom.v6i1.4594

Sindrom metabolik (SM) merupakan suatu kumpulan faktor risiko metabolik yang berkaitan langsung terhadap terjadinya penyakit kardiovaskular aterosklerosis. Tingginya penyebab kematian penyakit kardiovaskular dengan faktor risiko sindrom metabolik menjadi perhatian untuk dilakukan upaya pencegahan. Gereja Bethel Indonesia (GBI) Diaspora Sejahtera Surabaya memiliki visi membawa keselamatan bagi semua orang dengan filosofi memperhatikan keselamatan dan kebutuhan sesama. Salah satu kebutuhan saat ini adalah kesehatan jemaat. Banyaknya jumlah jemaat dan lansia berpotensi mengalami penurunan kesehatan akibat gangguan metabolisme. Risiko gangguan metabolisme kurang dipahami oleh masyarakat awam termasuk jemaat GBI Diaspora Sejahtera Surabaya. Permasalahan yang dihadapi jemaat di GBI Diaspora Sejahtera Surabaya adalah kurangnya pengetahuan tentang pencegahan dan penanganan penyakit akibat gangguan metabolisme. Solusi yang ditawarkan melalui pengabdian masyarakat di GBI Diaspora Sejahtera Surabaya adalah edukasi penyakit terkait akibat gangguan metabolisme, pemeriksaan darah yang meliputi kolesterol, asam urat, gula darah serta konsultasi, serta deteksi dini penyakit diabetes melalui pemberian buku diary metabolisme yang diumumkan kepada peserta. Buku harian metabolisme ini berisi informasi skrining, pencegahan, dan penanganan gangguan metabolisme. Capaian dari pengabdian masyarakat ini adalah meningkatnya pengetahuan komunitas terhadap sindrom metabolik dan upaya mandiri untuk mencegah sindrom metabolik.

Gambaran Status Nutrisi pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis di Kota Surabaya: Description of Nutritional Status in Patients with Chronic Kidney Diseasepatients Undergoing Hemodialysis in the City of Surabaya Stephanie Laurensia Budi; Yuswanto Setyawan; Cempaka Harsa Sekarputri
Jurnal Surya Medika (JSM) Vol. 10 No. 3 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i3.6113

Penyakit ginjal kronik adalah penurunan bertahap fungsi ginjal, dimana terjadi kerusakan atau laju filtrasi glomerulus (LFG) di bawah 60 mL/menit selama minimal 3 bulan, menyebabkan ketidakmampuan tubuh untuk menjaga keseimbangan elektrolit dan cairan. Kasus gagal ginjal yang telah mencapai kategori stadium akhir serta ginjal yang tidak berfungsi, memerlukan hemodialisis untuk mengeluarkan zat racun yang ada di dalam tubuh. Akan tetapi, selain bisa membuang zat berbahaya dan cairan yang berlebih, hemodialisis juga bisa menghilangkan nutrisi yang sangat masih dibutuhkan oleh tubuh, layaknya glukosa, protein, serta juga vitamin larut air, dan mineral. Tujuan: Mengetahui gambaran dari status nutrisi yang ada pada pasien penyakit ginjal kronik yang sudah menjalani terapi hemodialisis di kota Surabaya. Metode: Penelitian ini merupakan penelitian deskriptif observasional dengan menggunakan metode cross sectional. Penelitian ini dilakukan melalui wawancara menggunakan kuisioner Dialysis Malnutrition Score serta dilakukan pengukuran antropometri pada pasien penyakit ginjal kronik yang menjalani hemodialisis di kota Surabaya. Hasil: pasien penyakit ginjal kronik yang menjalani hemodialisis di kota Surabaya mengalami malnutrisi tahap ringansedang sebanyak 65 orang (68%), sebagian besar memiliki indeks massa tubuh yang normal sebanyak 54 orang (56%), sebagian besar memiliki lingkar lengan atas yang normal sebanyak 60 orang (62%), dan Sebagian besar memiliki lingkar perut yang berlebihan sebanyak 45 orang (47%). Kesimpulan: Jumlah pasien gagal ginjal kronik yang menjalani hemodialisa di kota Surabaya sebagian besar mengalami penurunan status nutrisi pada tahap ringan-sedang dengan jumlah 65 orang atau sebesar 68% dari 96 total responden.

Enterocutaneous fistula et cause abdominal tuberculosis in community: An emergency diagnosis challenge Hadi, Siusanto; Ferdinandus, Pieter David Adriaan; Wartiningsih, Minarni; Messakh, Billy Daniel; Agung, Purwakaning Purnomo; Sekarputri , Cempaka Harsa; Gonaldy, Vincent Aurelius
Malahayati International Journal of Nursing and Health Science Vol. 7 No. 11 (2025): Volume 7 Number 11
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v7i11.627

Background: A fistula is defined as an abnormal connection that connects two hollow spaces of the body. Fistula are divided into two categories, internal and external. Abdominal TB can mimicks other diseases including Enterocutaneous fistula that occur due to chron’s disease, malignancy, typhoid or radiation exposure. Tuberculosis is a rare cause of enterocutaneous fistula increasing the needs of clinicians to diagnose TB in an emergency manner. Purpose: To assess clinical manifestation of enterocutaneous fistula in patient with abdominal tuberculosis, and to determine the best emergency diagnosis tools in the progress of diagnosing abdominal tuberculosis. Method: This literature review is guided by the PICOS framework, encompassing materials published from 2000 to 2024. Data were obtained from diverse sources such as PubMed Central, Google Scholar, Science Direct, Elsevier (SCOPUS), scientific journals, articles, and books. The analysis proceeded through three stages: data reduction, presentation, and formulation of conclusions. Studies fulfilling the inclusions criteria were selected. Results: Patient with TB could have enterocutaenous fistula as one of its clinical manifestations, therefore. This study concludes that multiplex PCR shows an outstanding result for its specificity making it highly effective in ruling out non-tubercular diseases with minimum false positive. Conclusion: Enterocutaneous fistula in intestinal tuberculosis often presents without clear thoracic imaging of pulmonary TB, complicating diagnosis. Abdominal TB's non-specific symptoms can mimic other diseases, making CT scans and ultrasonography useful, though not definitive. Laparoscopy, combined with histological examination, remains the most reliable diagnostic tool. Laboratory tests like ADA levels, PCR, and culture are essential in confirming the diagnosis. A diagnostic algorithm and early anti-tubercular therapy can help when test results are inconclusive.

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