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All Journal Indonesian Journal of Jamu
Maulita Indrisari
Department of Pharmacotherapy, Faculty of Medicine, Universitas Palangka Raya, Palangka Raya, 73118, Central Kalimantan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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Formulation and Evaluation of Antidesma bunius Gel: Antibacterial Activity, Stability, and Skin Irritation Nur Khairi; Maulita Indrisari; Maria Ulfa; Fhahri Mubarak
Jurnal Jamu Indonesia Vol. 11 No. 4 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i4.482

Abstract

Acne is associated with the proliferation of acne-related bacteria, particularly Propionibacterium acnes and Staphylococcus epidermidis. This study evaluated the antibacterial activity, physical stability, microbiological quality, and skin irritation potential of an Antidesma bunius extract gel. The extract was tested against both bacterial species using an agar diffusion method, and a gel containing 2.5% extract was prepared with different Carbopol concentrations. The extract produced inhibition zones of 13.31–23.64 mm, whereas the gel formulations produced inhibition zones of 17.51–19.69 mm. The formulations remained homogeneous and showed acceptable organoleptic properties, pH, viscosity, spreadability, and adhesion after stability testing. Total plate and yeast and mold counts met the applicable microbiological limits. No erythema or edema was observed in albino rabbits. These findings indicated that A. bunius extract gel has potential as a topical anti-acne formulation.
Co-Authors Fhahri Mubarak Maria Ulfa Nur Khairi