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p-Index From 2021 - 2026
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All Journal Jurnal Biologi Tropis Research of Service Administration Health and Sains Healthys
Alya Nabila Putri
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Public Health

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Gastroesophageal Reflux Disease: A Comprehensive Literature Review Baiq Salwa Nadira Alifa; Velda Mufarrihati Jacindalya; Desak Putu Candraningtyas; M. Badzlul Rahmansyah; Alya Nabila Putri; Faiza Firdausy; I Nyoman Rhino Raditya; Safrizal Raditya Wardana; Syifa’ul Layaliy; Baiq Widya Kaweryan; Istiazah Ramadhani; Latifa Ainun Pratiwi; Muh. As’ad Hamzah
Jurnal Biologi Tropis Vol. 26 No. 2 (2026): April - Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.11692

Abstract

Gastroesophageal Reflux Disease (GERD) is a chronic gastrointestinal disorder with increasing global prevalence that adversely affects quality of life and may lead to complications such as Barrett’s esophagus and esophageal adenocarcinoma. This narrative review aimed to synthesize current evidence on the pathophysiology, clinical manifestations, diagnosis, and management of GERD. A literature search was conducted using Google Scholar, PubMed, NCBI, and ScienceDirect for peer-reviewed articles and clinical guidelines published between 2021 and 2026. Twenty-two relevant articles in English and Indonesian were included. GERD results from an imbalance between aggressive factors, including transient lower esophageal sphincter relaxation, hiatal hernia, increased intra-abdominal pressure, and impaired esophageal motility, and the esophageal mucosal defense system. Non-Erosive Reflux Disease (NERD) is the most common phenotype, accounting for approximately 60–70% of cases. Diagnosis is based on symptom assessment supported by validated tools such as the GERD-Q questionnaire, ambulatory pH monitoring, and endoscopy when indicated. Proton pump inhibitors remain the first-line pharmacological therapy, complemented by lifestyle modification, while surgery is reserved for refractory or complicated cases. A patient-centered, evidence-based approach integrating early diagnosis, appropriate treatment, and patient education is essential to improve outcomes and prevent disease progression.  
Parenting Challenges for Children with Down Syndrome and the Role of Social Support: A Literature Review Alya Nabila Putri; Titi Pambudi Karuniawaty; Tristina Wardhani
Research of Service Administration Health and Sains Healthys Vol. 7 No. 3 (2026): Research of Service Administration Health and Sains Healthys (September)
Publisher : Lembaga Penelitian dan Pendidikan (LPP) Mandala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58258/gxf7ja15

Abstract

Down Syndrome is a genetic disorder caused by trisomy of chromosome 21 that affects children's physical, cognitive, and health development throughout their lifespan. This condition requires complex, long-term monitoring and care, which may generate parenting stress, particularly for mothers as the primary caregivers. This literature review was conducted to examine the relationship between social support and parenting stress among parents of children with Down Syndrome based on published scientific literature. A narrative review method was applied to relevant journal articles, books, and clinical guidelines concerning Down Syndrome, parenting stress, and social support. The review found that children's clinical characteristics, the need for continuous medical care, and the psychosocial burden accompanying the care of children with DS contribute to elevated parental stress. Social support from family, friends, and professionals was shown to act as a protective factor that reduces this stress. Strengthening social support networks should become part of nursing and public health interventions for families of children with Down Syndrome to improve parents' psychological well-being and the quality of childcare.
Co-Authors Baiq Salwa Nadira Alifa Baiq Widya Kaweryan Desak Putu Candraningtyas Faiza Firdausy I Nyoman Rhino Raditya Istiazah Ramadhani Latifa Ainun Pratiwi M. Badzlul Rahmansyah Muh. As’ad Hamzah Safrizal Raditya Wardana Syifa’ul Layaliy Titi Pambudi Karuniawaty Tristina Wardhani Velda Mufarrihati Jacindalya