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All Journal Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara
Lidya Imelda Laksmi
Department of Anatomical Pathology, Universitas Sumatera Utara
Humanities Health Professions Medicine & Pharmacology Public Health

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EKSPRESI IMUNOHISTOKIMIA PZIP7 PADA INVASIVE BREAST CARCINOMA UNTUK MERAMALKAN AGRESIVITAS TUMOR DAN RESISTENSI KEMOTERAPI: IMMUNOHISTOCHEMICAL EXPRESSION OF PZIP7 IN INVASIVE BREAST CARCINOMA TO PREDICT TUMOR AGGRESSIVENESS AND CHEMOTHERAPY RESISTANCE Winda Hasibuan; Betty; Lidya Imelda Laksmi; Jessy Chrestella; Devi Nafilah Yuzar
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 25 No. 2 (2026): Juli 2026
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v25i2.1220

Abstract

Invasive breast carcinoma (IBC) bersifat herediter dan paparan estrogen jangka panjang adalah faktor risikonya. Subtipe molekuler IBC dibagi menjadi luminal A, luminal B, HER2-positif, dan triple negatif breast cancer (TNBC). Subtipe molekuler adalah dasar bagi pemberian targeting dan personalized therapy. Resistensi dapat muncul dalam terapi kanker payudara. Untuk menilai resistensi sel-sel kanker payudara setelah pemberian terapi, American Joint Committee on Cancer (AJCC) ke-8 merekomendasikan penggunaan metode Residual Cancer Burden (RCB). Zink berfungsi untuk menstabilkan struktur global p53, selain itu gangguan pada homeostasis zink yang diperantarai oleh transporter terbukti menyebabkan proliferasi sel-sel kanker. Salah satu transporter yang berperan dalam meningkatkan konsentrasi zink di sitoplasma adalah ZIP7. pZIP7 adalah ZIP7 yang telah teraktivasi dan terfosforilasi. Penelitian ini dilakukan dengan pendekatan cross sectional dimulai bulan Juni 2025 sampai Februari 2026 (n=64) pada sediaan histopatologi dengan pulasan hematoxylin-eosin (HE), sediaan imunohistokimia subtipe molekuler IBC dan telah mendapatkan kemoterapi neoadjuvant. Pada penelitian ini IBC paling banyak dijumpai pada kelompok usia 40-49 tahun, subtipe histopatologi IBC NST, subtipe molekuler tipe luminal, dan Nottingham grading system grade 2, ypT3 dan ypN0. RCB class terbanyak adalah class II. Ekspresi imunohistokimia pZIP7 paling banyak dijumpai pada ekspresi imunohistokimia positif di sitoplasma sel-sel tumor dan tidak didapatkan hubungan yang signifikan antara ekspresi pZIP7 dan RCB (p-value: 0.371). Kesimpulan: Ekspresi imunohistokimia pZIP7 belum dapat meramalkan agresivitas dan resistensi terhadap kemoterapi neoadjuvan.
CLINICOHISTOPATHOLOGICAL CHARACTERISTICS OF PROSTATE LESIONS AT RUMAH SAKIT PENDIDIKAN PROF. DR. CHAIRUDDIN PANUSUNAN LUBIS MEDAN, 2023-2024: KARAKTERISTIK KLINIKOHISTOPATOLOGI LESI PROSTAT DI RUMAH SAKIT PENDIDIKAN PROF. DR. CHAIRUDDIN PANUSUNAN LUBIS MEDAN, 2023–2024 Lidya Imelda Laksmi; Causa Trisna Mariedina; Betty; Joko S Lukitoa; Arie Widiansyah Hasibuan
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 26 No. 1 (2027): Januari 2027
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v26i1.1355

Abstract

Prostatic enlargement is a global health problem among older men, caused by non-neoplastic or neoplastic lesions and commonly presenting as lower urinary tract symptoms. Benign Prostatic Hyperplasia (BPH) is the leading non-neoplastic etiology, whereas Acinar Prostatic Carcinoma (APC) is the most common malignant neoplasm. High-Grade Prostatic Intraepithelial Neoplasia (HGPIN), a precursor lesion, and Atypical Small Acinar Proliferation (ASAP), a suspicious atypical acinar proliferation, are critical differential diagnoses and pitfalls influencing management and prognosis. Using total sampling, this retrospective cross-sectional study characterized clinicohistopathological features of prostatic lesions in patients undergoing prostate core needle biopsy and/or transurethral resection of the prostate at Rumah Sakit Pendidikan Prof. dr. Chairuddin Panusunan Lubis Medan, from January 2023 to June 2024. Histopathological evaluation used hematoxylin and eosin staining. Forty-three specimens were analyzed descriptively: 33 (76.74%) were BPH and 10 (23.26%) were APC; neither ASAP nor HGPIN was identified. Benign and malignant lesions occurred most frequently among patients aged 60–69 years; the youngest were aged 50–59 years. Ultrasonographic diagnoses agreed with histopathology in 83.33% of BPH cases and 66.67% of APC cases. BPH specimens predominantly showed papillary infolding and cystic atrophy, corpora amylacea as the principal intraluminal secretion, and squamous metaplasia as a distinctive finding. APC specimens predominantly showed tufting, cribriform, and micropapillary architectures; blue mucin and crystalloids as intraluminal secretions; and signet-ring cell morphology as a distinctive finding. Benign lesions showed papillary infolding and cystic atrophy, with intraluminal corpora amylacea. Malignant lesions showed tufting, cribriform and micropapillary patterns, with intraluminal blue mucin and crystalloids.
Co-Authors Arie Widiansyah Hasibuan Betty Causa Trisna Mariedina Devi Nafilah Yuzar Jessy Chrestella Joko S Lukitoa Winda Hasibuan