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All Journal Jurnal Kesehatan Masyarakat
Susy Tjahjani
Universitas Kristen Maranatha
Education Public Health

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A.galanga (L.)-Willd Rhizome and O.sanctum L. Leave Essential Oils as Culex sp. Larvicide Sugiarto Puradisastra; Regina Aurellia Limijaya; Angelica Rosa Septiana Hartono; Susy Tjahjani
Jurnal Kesehatan Masyarakat Vol. 20 No. 3 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i3.3388

Abstract

Culex sp. can transmit diseases such as encephalitis and filariasis which is a public health problem because of elephantiasis, disability, and a neglected tropical disease. To prevent these diseases, the mosquitoes need to be eradicated and larvicides are considered to control them at their early stage. Temephos, a synthetic larvicide, could cause several disadvantage, such as potential toxicity against non-target organisms and easierto-develop mosquito resistance. Botanical sources from Indonesian spices i.e. galangal (Alpinia galanga (L.) Willd.) and basil (Ocimum sanctum L.) are potentially used as larvicide. This study aimed to explore the larvicidal effect of their essential oils compared against temephos against Culex sp. A true experimental study was done using several concentrations and replications of these essential oils in each container, consisting of 25 third instar of Culex sp larvae for 24 hours at room temperature according to WHO procedure. The percentage of dead larvae was analyzed by ANOVA/ Kruskal Wallis. The study showed that Alpinia galanga ( L.) Willd. and Ocimum sanctum L. essential oils had larvicide activity and their activity starting from 140 ppm and 400 ppm consecutively was the same as temephos 1 ppm.
The Ins and Outs of Alpha-mangostin’s Potential as an Antimalarial Susy Tjahjani; Faizal Hermanto; Muchtaridi Muchtaridi; Diah Lia Aulifa; Fahmi Ahsanul Haq
Jurnal Kesehatan Masyarakat Vol. 20 No. 4 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i4.19307

Abstract

Malaria drug resistance, including to development of resistance against artemisinin based treatments, poses a major challenge to elimination efforts. Alpha-mangostin, an antioxidant with in vitro antimalarial activity, is hindered by its poor solubility. This study explores the antimalarial effects of water-soluble alpha-mangostin chitosan-alginate nanoparticles (ACAN) in mice with berghei malaria. Mice were treated with various doses of ACAN, compared to alpha-mangostin in polyethylene glycol (PEG), as well as in corn oil (ACO) and chloroquine as a standard. Growth inhibition rates were assessed, revealing no inhibition in the PEG and normal control (NC) groups, while ACO was less active. The effective dose 50 (ED50) of ACAN was 264.5 mg/kg BW, containing only 15.87 mg of alpha-mangostin, suggesting that alpha-mangostin in ACAN may offer promising in vivo antimalarial activity. Further investigation is needed.
Co-Authors Angelica Rosa Septiana Hartono Diah Lia Aulifa Fahmi Ahsanul Haq Faizal Hermanto Muchtaridi Muchtaridi Regina Aurellia Limijaya Sugiarto Puradisastra