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All Journal Journal of Research in Pharmacy and Pharmaceutical Sciences
jihan astuti
UPNVJ
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Other

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EVALUATION OF POLYPHARMACY IN GERIATRIC PATIENTS PARTICIPATING IN THE CHRONIC DISEASE MANAGEMENT PROGRAM (PROLANIS) jihan astuti; Salsabilla Wandira1; salma rahmadani; afdhal hanania; kharazi vitonova
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 4 No 2 (2025): Vol.4 No.2 DECEMBER (2025)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

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Abstract

Chronic diseases such as type 2 diabetes mellitus and hypertension remain highly prevalent worldwide, including in Indonesia. The geriatric population is particularly vulnerable because of their susceptibility to polypharmacy, which increases the risk of adverse outcomes. This study aimed to evaluate polypharmacy among geriatric patients, especially participants of the PROLANIS, using a Systematic Literature Review (SLR). A literature search was conducted through Google Scholar following PRISMA guidelines. Of 40 articles identified, only three met the inclusion criteria, consisting of publications from the last 10 years indexed by SINTA and SCOPUS. The review included 350 geriatric patients, most aged ≥60 years and predominantly female. The main chronic conditions were hypertension and diabetes mellitus, with Lisni et al. (2025) specifically reporting type 2 diabetes. Polypharmacy was strongly associated with drug interactions, where moderate-severity combinations such as glimepiride-metformin (18.6%) were most frequent, and pioglitazone-clopidogrel was categorized as high-severity. These interactions mainly increased the risk of hypoglycemia, while others reduced antidiabetic effectiveness. Utaminingrum et al. (2015) emphasized polypharmacy in the broader context of irrational drug use, including self-medication and antibiotic overuse. Factors linked to polypharmacy included the number of prescribed drugs and education level, while age and gender showed no significant associations.
THE RELATIONSHIP OF ANEMIA AND NUTRITIONAL STATUS WITH QUALITY OF LIFE AMONG ADOLESCENT GIRLS IN WEST JAKARTA jihan astuti
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 4 No 2 (2025): Vol.4 No.2 DECEMBER (2025)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v4i2.13766

Abstract

Adolescent girls are at increased risk of anemia due to rapid growth, hormonal changes, and regular menstrual blood loss. Anemia may result in fatigue, psychological disturbances, reduced self-esteem, and impaired social functioning, all of which can diminish quality of life. However, the extent to which anemia severity and nutritional status influence quality of life remains unclear. This cross-sectional study examined the relationship between anemia severity, nutritional status, and quality of life among adolescent girls. The sample comprised 111 girls diagnosed with anemia at a Primary Health Center, based on hemoglobin levels, selected through purposive sampling. Quality of life was assessed using the WHOQOL-BREF, which evaluates physical, psychological, social, and environmental domains. Data were analyzed using the Chi-square test. The findings indicated a significant association between anemia severity and overall quality of life (p = 0.048). In contrast, nutritional status, as measured by body mass index, was not significantly associated with either quality of life (p = 0.499) or anemia severity (p = 0.598). These results suggest that anemia severity is a key determinant of quality of life in adolescent girls, whereas nutritional status alone does not exert a substantial effect.
Co-Authors afdhal hanania kharazi vitonova Salma Rahmadani Salsabilla Wandira1