<![CDATA[Twenty first century chemistry education requires learning resources that not only improve conceptual understanding but also foster students' creativity and independent learning. However, existing Acid base practicum guides generally emphasize laboratory procedures and have not integrated ethnoscience and Chemo-Entrepreneurship (CEP) in a single instructional resource. This study aimed to develop and validate an ethnoscience and CEP integrated Acid base practicum guide for senior high school chemistry. Educational Design Research (EDR) employing the Plomp model was selected because it provides a systematic framework for designing and validating educational products before classroom implementation. The study was limited to the preliminary research and prototyping phases. Product validity was evaluated through expert review involving five validators and one-to-one evaluation with three students representing different academic ability levels. Validity data were analyzed using Aiken's V. The practicum guide achieved an overall Aiken's V value of 0.93, indicating high validity, with content, presentation, language, and graphical validity indices of 0.93, 0.95, 0.92, and 0.95, respectively. The one-to-one evaluation further demonstrated that students considered the guide clear, systematic, and easy to follow. These findings provide empirical evidence that integrating ethnoscience and Chemo-Entrepreneurship within a chemistry practicum guide is feasible while maintaining scientific validity, thereby offering a contextual instructional resource has the potential to support creativity and independent learning in senior high school chemistry.]]>
