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All Journal Biology, Medicine, & Natural Product Chemistry
Williams Balela Balela
Regional Center for Atomic Energy of Kinshasa
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Phytochemical Study, in vitro Antioxidant Activities and in vitro Determination of Free Glucose Concentration when Brought into Contact with Extracts of Tetracera rosiflora (Dillenianaceae) Leaves Christophe Muanyishay Lukanda; Giresse Kasiama Nkal; Williams Balela Balela; Carlos Kabengele Nkongolo; Pierre Luhata Lokadi; Sebastien Luyindula Ndiku; Nadège Ngombe Kabamba; Pius Mpiana Tshimankinda
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.1555-1563

Abstract

Tetracera rosiflora Gilg (Dilleniaceae) is a medicinal plant traditionally used in the Congolese pharmacopoeia to treat various diseases, including diabetes. This study aimed to determine the phytochemical composition, evaluate the in vitro antioxidant potential, and assess the glucose-lowering capacity of T. rosiflora leaf extracts. Phytochemical screening revealed the presence of coumarins, iridoids, anthocyanins, polyphenols, flavonoids, and tannins. Quantitative assays indicated total polyphenols (42.12 ± 1.14 mg GAE/g), flavonoids (0.090 ± 0.002 mg QE/g), and anthocyanins (0.30 ± 0.07 mg CE/g). The quantification of mineral elements by x-ray fluorescence revealed 29 elements with hight conecntration of Ca, K, S and Mg. The organic extracts exhibited strong antioxidant activity by scavenging ABTS and DPPH radicals, with higher efficacy in the ABTS assay (IC50: 5.48 ± 3.23 µg/mL for ethanol extract; 25.65 ± 8.67 µg/mL for dichloromethane extract) compared to DPPH (IC50: 10.81 ± 0.86 µg/mL and 96.16 ± 16.73 µg/mL, respectively). Furthermore, in vitro glucose-binding assays demonstrated that organic extracts markedly reduced free glucose concentrations, confirming their potential antidiabetic activity. These findings support the traditional use of T. rosiflora and highlight its promise as a source of natural antioxidant and hypoglycemic agents.
Co-Authors Carlos Kabengele Nkongolo Christophe Muanyishay Lukanda Giresse Kasiama Nkal Nadège Ngombe Kabamba Pierre Luhata Lokadi Pius Mpiana Tshimankinda Sebastien Luyindula Ndiku