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All Journal Journal of Pharmaceutical and Sciences. SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Lusia Eka Putri
Department of Pharmacy, Universitas Dharma Andalas, Padang, West Sumatra, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Evaluasi Aktivitas Penghambatan α-Amilase, α-Glukosidase, dan Aktivitas Antioksidan secara In Vitro dari Ekstrak Etanol Lima Sayuran Indonesia: Pendekatan Multivariat dan Korelasi Nofrizal Nofrizal; Fatma Haspa Anzalmi; Lusia Eka Putri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1806

Abstract

Postprandial hyperglycemia and its associated oxidative stress are recognized as pivotal pathological hallmarks driving the progression of type 2 diabetes mellitus and its vascular complications. This study aims to evaluate and comparatively analyze the in vitro α-amylase, α-glucosidase inhibitory activities, alongside the free radical scavenging capacities, of ethanolic extracts derived from five widely consumed fresh vegetables in Indonesia: Carica papaya, Momordica charantia, Gigantochloa atter, Diplazium esculentum, and Luffa acutangula. Bioactivity assays were conducted utilizing starch-iodine, p-nitrophenyl-α-D-glucopyranoside, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) methodologies. The experimental findings demonstrated that D. esculentum extract exhibited the most pronounced dual-inhibitory efficacy against α-amylase (IC50 138.50 µg/mL) and α-glucosidase (IC50 38.20 µg/mL). Furthermore, D. esculentum and C. papaya extracts demonstrated strong antioxidant capacities among all evaluated samples. Principal Component Analysis (PCA) and Pearson correlation analyses confirmed a strong positive correlation between free radical scavenging capacity and carbohydrate-hydrolyzing enzyme inhibition. In conclusion, D. esculentum emerges as a premier functional vegetable candidate, exhibiting remarkable dual-action therapeutic properties for the attenuation of postprandial hyperglycemia and mitigation of oxidative stress.
Effect Of Postharvest Drying Methods On Total Flavonoid Content, Total Phenolic Content, Antioxidant Activity, And Sensory Acceptance Of Coffee Mistletoe (Scurrula ferruginea [Roxb. Ex Jack] Danser) Tea Nofrizal; Shinta Angelia Astarie; Lusia Eka Putri
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 5 No. 1 (2026): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v5i1.238

Abstract

Postharvest drying is a critical step in herbal tea processing as it affects the quality of simplicia, phytochemical content, biological activity, and sensory characteristics of the product. This study aimed to evaluate the effect of postharvest drying methods on total flavonoid content, total phenolic content, antioxidant activity, and sensory acceptance of coffee mistletoe (Scurrula ferruginea [Roxb. ex Jack] Danser) leaf tea. Coffee mistletoe leaves were dried using three different methods: sun drying, oven drying at 40°C, and room-temperature air drying. The dried samples were characterized physicochemically and analyzed for total flavonoid content (AlCl₃ method), total phenolic content (Folin–Ciocalteu method), and antioxidant activity using the DPPH radical scavenging assay (IC₅₀). A sensory acceptance test involving 20 panelists was conducted to evaluate aroma, color, and taste of the tea infusion. The results showed that the drying method significantly affected all evaluated parameters (p < 0.05). Sun drying produced the highest total flavonoid content (2.15 mmol QE/100g sample) and the highest sensory acceptance. Room-temperature drying resulted in the highest total phenolic content (51.41 mmol GAE/100g sample) and the strongest antioxidant activity with the lowest IC₅₀ value (86.4 µg/mL). Oven drying was the most effective in reducing moisture content but led to the greatest losses in flavonoids, phenolics, antioxidant activity, and sensory quality. In conclusion, room-temperature drying is more suitable for maximizing antioxidant potential, whereas sun drying is preferable for producing herbal tea with better consumer acceptance.
Co-Authors Fatma Haspa Anzalmi Nofrizal Nofrizal Nofrizal Shinta Angelia Astarie