Critical thinking skills of students on circulatory system material still need to be improved through media that encourages active involvement in learning. Questionnaire results show that 61.9% of students find circulatory system material the most difficult, and students still struggle to answer cognitive level questions C4–C5 on the indicators of interpretation, analysis, and inference. Students are more enthusiastic when learning involves games compared to conventional PowerPoint, motivating the researcher to develop Spin Game-based media for more interactive learning. This study aims to produce PowerPoint Spin Game media integrated with ClassPoint on grade XI circulatory system material and to determine its validity, practicality, and effectiveness in improving students' critical thinking skills. This research is a development study using the ASSURE model comprising the stages of Analyze Learners, State Standards and Objectives, Select Strategies, Technology, Media and Materials, Utilize Media and Materials, Require Learner Participation, and Evaluate and Revise. A limited trial was conducted on 36 grade XI students. Results show the media is very valid with an average of 92.58%, very practical based on learning implementation observation of 97.62% and student response of 96.88%, and effective with an N-Gain of 0.71 categorized as high, with an average posttest score of 83.28. Therefore, PowerPoint Spin Game media integrated with ClassPoint developed through the ASSURE model is declared feasible to improve critical thinking skills of grade XI students.