As the pace of change in society and technology accelerates, Indonesia’s education system must continue to be improved and adapted to meet the needs of society in the 5.0 era. With the passage of time and technological advancements, the format of student worksheets has evolved from a printed (paper) version to a digital version, known as the Electronic Student Worksheet or E-LKPD. There are various platforms or applications that can support the development of E-LKPD, one of which is Wizer.me. This study aims to develop digital teaching materials in the form of interactive E-LKPDs using Wizer.me to teach the topic of changes in natural conditions to fifth-grade students at SDN 1 Trenceng in Tulungagung Regency. This study employs the ADDIE development model, which consists of five stages: Analysis, Design, Development, Implementation, and Evaluation. The subjects of this study were fifth-grade students at SDN 1 Trenceng, consisting of 18 students. Product validation was conducted by subject matter experts and media experts, and supplemented with a practicality test through teacher response questionnaires and student response questionnaires. Based on the research results, the validation of the digital E-LKPD teaching materials assisted by Wizer.me by the two subject matter experts yielded score percentages of 96% and 100%, respectively. Meanwhile, the validation by the two media experts yielded scores of 98% and 98%. These two validation results indicate that the developed E-LKPD falls into the “Highly Valid” category. Additionally, the teacher response survey results reached a percentage of 100%, and the student response survey results reached 92%, indicating that this teaching material falls into the “Highly Practical” category. Therefore, it can be concluded that the digital teaching material in the form of interactive E-LKPD supported by Wizer.me is valid and suitable for implementation with fifth-grade elementary school students