Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Jurnal Akta Trimedika
Laksmi Maharani
Fakultas Kedokteran, Unversitas Trisakti, Jakarta, Indonesia

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
PROTEIN SOLUBLE SUPPRESSION OF TUMORIGENICITY 2 (sST2) SEBAGAI PENANDA KERUSAKAN KARDIOVASKULAR PADA PREEKLAMSIA Laksmi Maharani
Jurnal Akta Trimedika Vol. 1 No. 2 (2024): April 2024
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/aktatrimedika.v1i2.19706

Abstract

Preeclampsia as a pregnancy complication was still a direct cause of maternal death, especially in developing countries. The process of abnormal trophoblast invasion as a pathophysiology of preeclampsia would cause an ischemic environment in the placenta. This situation caused the placenta to release pro-inflammatory cytokines and anti-angiogenic factors into the maternal circulation, resulting in the vasocontriction of blood vessels, endothelial dysfunction in the vasculature of maternal organs, and the production of different clinical features depending on the organs affected. Vascular and myocardial muscle damage was a complication that causes cardiovascular disorders and could increase maternal morbidity and mortality in preeclampsia. sST2 as part of the interleukin (IL)-1 receptor, was a biomarker used to indicate myocardial muscle damage in cardiac disease. There had been a growing number of research investigating the use of sST2 as a marker of cardiac muscle damage in patients with heart failure. Some of them concluded that sST2 can be used as a predictor of acute cardiac muscle damage. Others stated that sST2 as a marker could accompany chronic cardiac defects. Preeclampsia, as a disease in pregnancy that showed damage to maternal organs, was starting to be studied using this biomarker as a marker for damages to the cardiac organ. There were studies that showed differences in sST2 levels in preeclampsia with and without complications. Preeclampsia with cardiac complications was characterized by damage to the myocardial muscle, especially to the left ventricular area. The sST2 protein was starting to be used as a marker for this damage. Further research was still being carried out to improve the use of this biomarker as a marker for other damage to the maternal cardiac organ.
HUBUNGAN JUMLAH PARITAS DAN USIA MENOPAUSE Salsabilla Rizkiana; Laksmi Maharani
Jurnal Akta Trimedika Vol. 2 No. 4 (2025): Oktober 2025
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/

Abstract

Latar Belakang: Menopause merupakan fase transisi dari masa produktif ke non produktif yang ditandai dengan berhentinya menstruasi minimal 12 bulan, umumnya terjadi pada perempuan usia 50 tahun. Salah satu faktor yang memengaruhi usia menopause adalah jumlah paritas. Peningkatan paritas dapat memperlambat menopause melalui peningkatan reseptor Anti-Müllerian Hormon (AMH) yang menghambat perekrutan folikel ovarium. Studi ini bertujuan menganalisis hubungan jumlah paritas dengan usia menopause. Metode: Penelitian cross sectional dilaksanakan pada bulan September - November tahun 2024 di Puskesmas Cirimekar, Kabupaten Bogor. Penelitian ini melibatkan 174 responden perempuan usia 40-60 tahun yang sudah mengalami menopause. Pemilihan responden menggunakan teknik non-random consecutive sampling. Data jumlah paritas dan usia menopause didapatkan melalui kuesioner. Distribusi data jumlah paritas dibedakan menjadi nullipara, primipara, multipara dan grandemultipara. Untuk usia menopause dibedakan menjadi onset dini, onset normal, dan onset terlambat.  Analisis statistik menggunakan chi-square dengan nilai p ≤ 0,05 memiliki hubungan yang bermakna atau signifikan. Hasil: Pada kelompok nullipara didapatkan jumlah usia menopause tidak normal lebih banyak daripada usia menopause normal yaitu 11 responden (61,1%). Sementara pada kelompok multipara didapatkan persentase usia menopause normal yang lebih tinggi yaitu 114 responden (73,1%).  Hubungan antara jumlah paritas dan usia menopause didapatkan bermakna dengan nilai p = 0,003. Simpulan: Terdapat hubungan bermakna antara jumlah paritas dengan usia menopause
Co-Authors Salsabilla Rizkiana