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Moehamad Orliando Roeslan
Department of Oral Biology, Faculty of Dentistry, Universitas Trisakti, Jakarta, Indonesia

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Effect of Clinacanthus nutans Leaf Chloroform Extract on Reducing Nitric Oxide in Fibroblasts Erdita Hapsari; Rezky Anggraeni; Komariah Komariah; Moehamad Orliando Roeslan
Scientific Dental Journal Vol. 7 No. 3 (2023): Sep-Dec
Publisher : Faculty of Dentistry, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/sdj.v7i3.19345

Abstract

Background: Clinacanthus nutans or dandang gendis is a plant that can be an effective herbal treatment for inflammation, in addition that the Indonesian people are still looking for alternative treatments. Research shows that the anti-inflammatory properties of C. nutans leaves are effective in reducing inflammation against fibroblasts. Nitric oxide is one of the inflammatory mediators, that release by fibroblast when inflamed. Objective: To observe the effect of C. nutans leaf chloroform extract on reducing nitric oxide in inflamed fibroblasts. Methods: Fibroblasts stimulated with Escherichia coli lipopolysaccharide were treated with chloroform extracts of C. nutans leaves at concentrations of 25, 50, 100, 200 μg/mL for 24 hours, then a nitric oxide inhibition test was performed. Result: The C. nutans leaf extract at a concentration of 200 μg/mL resulted in significantly (p < 0.05) lower nitric oxide production than the negative control. Conclusion: Clinacanthus nutans leaf chloroform extract has the effect of reducing nitric oxide in fibroblasts. This extract has the potential as an anti-inflammatory agent.
Effect of Fiber Resin Coating and Occlusal Preparation Thickness of Endocrown Restoration Jeffrey Dwijayana Susanto; Ade Prijanti Dwisaptarini; Selviana Wulansari; Janti Sudiono; Moehamad Orliando Roeslan
Scientific Dental Journal VOLUME 8, ISSUE 1, JANUARY 2024
Publisher : Faculty of Dentistry, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/sdj.v8i1.19672

Abstract

Background: Teeth rehabilitation after root canal treatment with extensive crown loss is a challenge for clinicians. Endocrown restorations are indicated for cases of extensive loss of crown structure, in conditions where the use of posts does not possible. The use of fiber resin coating acts as a stress breaker and absorption on the dentin thereby increasing fracture resistance. Aim: To determine the effect of fiber resin coating as core build up material and occlusal preparations thickness on fracture resistance of endocrown restorations. Methods: An experimental study was conducted on 20 extracted molars and root canal treatment was performed. The samples were divided into four groups, which consist of with and without fiber resin coating, and with a different composite resin endocrown thickness. Fracture resistances were tested on the samples using a universal testing machine. Results: One-way ANOVA test showed a significant difference in fracture resistance value (p>0.05) between the tested groups. Tukey’s post hoc test results showed significant differences in all groups except for the thickness of 3.5 mm and 2 mm groups with FRC. Conclusion: There was a significant difference in fracture resistance between composite resin endocrown restorations with different thickness, either without fiber reinforced composite or using fiber reinforced composite as the core build up material.
Co-Authors Ade Prijanti Dwisaptarini Erdita Hapsari Janti Sudiono Jeffrey Dwijayana Susanto Komariah Komariah Rezky Anggraeni Selviana Wulansari