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Wisdawati Wisdawati
Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Lemongrass (Cymbopogon citratus) Essential Oil Ointment for Topical Therapy: Wound Healing Efficacy, Anti-Inflammatory Response, and Skin Irritation Assessment in Animal Models Wisdawati Wisdawati; Andi Trihadi Kusuma Kisra; Rais Razak; Selpida Handayani; Irma Santi; Dewi Yuliana
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci (In Press)
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.27082

Abstract

Lemongrass (Cymbopogon citratus), containing citronellal, geraniol, and limonene, has demonstrated wound healing and anti-inflammatory potential. Lemongrass extract has been found to increase fibroblast numbers in rats, and formulated ointment containing its essential oil exhibit good characteristics. This study evaluated the wound healing, anti-inflammatory, and skin irritation potential of lemongrass essential oil ointment. Wound healing activity was assessed to compare  three formulation (F1:5%, F2: 10% and F3: 15%). Incision wounds were made in all groups and then treated according to groups assignment, the healing progression was measured on days 0, 3, 7, 10, 14 and 21. The ointment enhanced wound closure in a dose-dependent manner. As in the anti-inflammatory test, five animal groups were employed, with the positive group replaced by HOT-IN DCL emulgel®. Edema volume was recorded hourly for five hours following carrageenan induction. Also, the ointment demonstrated dose-dependent manner of anti-inflammatory activity. Skin irritation was evaluated according to non-clinical toxicity guidelines using three formulations on rabbit skin, and responses were scored using the Primary Irritation Index (PII). All formulations showed a PII value of 0, indicating negligible irritation. These findings support the potential of lemongrass essential oil ointment as a safe candidate for topical therapeutic development.
Lemongrass (Cymbopogon citratus) Essential Oil Ointment for Topical Therapy: Wound Healing Efficacy, Anti-Inflammatory Response, and Skin Irritation Assessment in Animal Models Wisdawati Wisdawati; Andi Trihadi Kusuma Kisra; Rais Razak; Selpida Handayani; Irma Santi; Dewi Yuliana
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci (In Press)
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.27082

Abstract

Lemongrass (Cymbopogon citratus), containing citronellal, geraniol, and limonene, has demonstrated wound healing and anti-inflammatory potential. Lemongrass extract has been found to increase fibroblast numbers in rats, and formulated ointment containing its essential oil exhibit good characteristics. This study evaluated the wound healing, anti-inflammatory, and skin irritation potential of lemongrass essential oil ointment. Wound healing activity was assessed to compare  three formulation (F1:5%, F2: 10% and F3: 15%). Incision wounds were made in all groups and then treated according to groups assignment, the healing progression was measured on days 0, 3, 7, 10, 14 and 21. The ointment enhanced wound closure in a dose-dependent manner. As in the anti-inflammatory test, five animal groups were employed, with the positive group replaced by HOT-IN DCL emulgel®. Edema volume was recorded hourly for five hours following carrageenan induction. Also, the ointment demonstrated dose-dependent manner of anti-inflammatory activity. Skin irritation was evaluated according to non-clinical toxicity guidelines using three formulations on rabbit skin, and responses were scored using the Primary Irritation Index (PII). All formulations showed a PII value of 0, indicating negligible irritation. These findings support the potential of lemongrass essential oil ointment as a safe candidate for topical therapeutic development.
Co-Authors Andi Trihadi Kusuma Kisra Dewi Yuliana Irma Santi Rais Razak Selpida Handayani