<![CDATA[Lemongrass (Cymbopogon citratus), containing citronellal, geraniol, and limonene, has demonstrated wound healing and anti-inflammatory potential. Lemongrass extract has been found to increase fibroblast numbers in rats, and formulated ointment containing its essential oil exhibit good characteristics. This study evaluated the wound healing, anti-inflammatory, and skin irritation potential of lemongrass essential oil ointment. Wound healing activity was assessed to compare  three formulation (F1:5%, F2: 10% and F3: 15%). Incision wounds were made in all groups and then treated according to groups assignment, the healing progression was measured on days 0, 3, 7, 10, 14 and 21. The ointment enhanced wound closure in a dose-dependent manner. As in the anti-inflammatory test, five animal groups were employed, with the positive group replaced by HOT-IN DCL emulgel®. Edema volume was recorded hourly for five hours following carrageenan induction. Also, the ointment demonstrated dose-dependent manner of anti-inflammatory activity. Skin irritation was evaluated according to non-clinical toxicity guidelines using three formulations on rabbit skin, and responses were scored using the Primary Irritation Index (PII). All formulations showed a PII value of 0, indicating negligible irritation. These findings support the potential of lemongrass essential oil ointment as a safe candidate for topical therapeutic development.]]>
Copyrights © 2026
