<![CDATA[Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease that causes long-term airflow limitation, and its burden continues to increase worldwide. Volatile Organic Compounds (VOC) found within exhaled breath have been studied as possible biomarkers for this condition. Obstructive Sleep Apnea (OSA) is one comorbidity that receives attention because it can be related to more frequent exacerbations and poorer outcomes within COPD. This cross-sectional observational study describes STOP-BANG score patterns among confirmed COPD patients and people with high COPD risk from three primary health care centers within Malang City. It also examines the relationship between STOP-BANG score and VOC components within both groups. Data were collected using the STOP-BANG (Snoring, Tiredness, Observed apnea, Pressure, BMI, Age, Neck circumference, Gender) questionnaire and VOC examination. A total of 102 patients were included, consisting of 49 men and 53 women. STOP-BANG score showed weak to moderate relationships with several VOC components, including carbon dioxide (CO2; r=0.286; p=0.014), ammonia (NH3; r=0.286; p=0.039), and benzene (C6H6; r=-0.253; p=0.033). Among patients with moderate-high OSA risk within the high-risk COPD group, the STOP-BANG score had a significant relationship with CO2, acetone (C3H6O; r=0.347; p=0.023), and propylene (C3H6; r=0.347; p=0.023). Smoking history was also significantly related to C6H6 (r=0.282; p=0.017) within the high-risk COPD group and carbon monoxide (CO; r=0.73; p=0.025) within the COPD group. Since findings remain exploratory, further confirmation using polysomnography is needed before VOC profiling can be used as an additional method for OSA risk screening within primary health care.]]>
