Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Majalah Farmaseutik Borneo Journal of Pharmacy
Marlyn Dian Laksitorini
Universitas Gadjah Mada
Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
PENGARUH DISREGULASI EPIGENETIK TERHADAP PATOLOGI PENYAKIT ALZHEIMER DAN TARGET TERAPI MELALUI JALUR EPIGENETIK Iradatul Ikhtiari; Marlyn Dian Laksitorini; Nunung Yuniarti
Majalah Farmaseutik Vol 22, No 3 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i3.117661

Abstract

The increase in life expectancy is directly proportional to the increasing prevalence of Alzheimer's disease. By 2050, it is estimated that 152 million people will be living with Alzheimer's disease. Alzheimer's disease is a disease caused by progressive neuronal damage, characterized by a decline in cognitive functions such as memory, concentration, and communication impairments. Molecularly, this disease is characterized by the presence of beta-amyloid (Aβ) plaques and tau protein neurofibrillary tangles (NFTs). The pathogenesis of Alzheimer's disease is associated with changes in epigenetic mechanisms, namely changes in DNA expression without involving changes in DNA sequence. Epigenetic mechanisms may contribute to the pathology of Alzheimer's disease through increased activity of the Bace1 and psen1/2 genes, which cleave APP. APP cleavage will predispose to the amyloidogenic pathway, producing toxic Aβ and facilitating tau protein NFTs. The role of epigenetic mechanisms is not limited to the pathology of Alzheimer's disease; several studies have assessed their potential as promising therapeutic targets. Through epigenetic reprogramming, several studies have shown encouraging results. This article reviews the role of epigenetic mechanisms in driving the development of Alzheimer's disease pathology and explores the potential of epigenetic reprogramming as a therapeutic strategy. Through this in-depth approach, it is hoped that this article will open new perspectives on the role of epigenetic mechanisms in Alzheimer's disease pathology and therapeutic targets.
Effect of Temperature and Heating Duration on Physical Properties and Antioxidant Activity of Gummy with Chrysanthemum Extract and Sacha Inchi Oil Zahra Salsabila; Wimala Hardyawati Putri Apsari; Ariel Immanuela; Muhammad Novrizal Abdi Sahid; Cici Darsih; Marlyn Dian Laksitorini
Borneo Journal of Pharmacy Vol. 9 No. 3 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i3.9696

Abstract

The chrysanthemum flower is known for its antioxidant activity and has recently been shown by many studies to exert neuroprotective effects. Sacha inchi oil is rich in omega-3 fatty acids, which are important for brain development and cognitive function. As a result, some studies have explored the addition of omega-3-containing oil to gummy candy supplements. Incorporating oily materials into gummy candy potentially affects the gummy's physicochemical properties. This study aims to optimize the temperature and heating duration during the preparation of the gummy candy containing sacha inchi oil and Chrysanthemum indicum flower extract using a 22 factorial design. Furthermore, the antioxidant activities of the starting material and the finished products were evaluated using the DPPH reduction assay. The physicochemical properties evaluated include organoleptic, pH, weight uniformity, water content, water activity, and texture. The study suggested that temperature and heating duration affect the color, water content, water activity, and texture of gummy candy. The IC₅₀ values of chrysanthemum flower extract, sacha inchi oil, and their combination before heating were 67.212, 318.838, and 233.602 µg/mL. Following the optimized heating process, the IC₅₀ values increased to 187.092, 408.753, and 541.529 µg/mL. It indicates that heat treatment significantly diminished the antioxidant capacity of the gummy candy formulations. The optimal condition for the final heating was achieved at 105°C for 7 minutes.
Co-Authors Ariel Immanuela Cici Darsih Iradatul Ikhtiari Muhammad Novrizal Abdi Sahid Nunung Yuniarti Wimala Hardyawati Putri Apsari Zahra Salsabila