Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Sains dan Komunitas Majalah Farmaseutik
Nunung Yuniarti
Universitas Gadjah Mada
Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
PHAGOCYTOSIS ACTIVITY OF BINAHONG (Anredera cordifolia (Tenore.) Steenis) FROM SECANG, MAGELANG, CENTRAL JAVA, INDONESIA Perdana Priya Haresmita; Dika Sotya Sakti; Nunung Yuniarti; Subagus Wahyuono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (756.485 KB) | DOI: 10.24071/jpsc.001693

Abstract

The use of medicinal plants is increasing due to the search for alternative resources to treat diseases such as hypertensions and infection. Along with the development in science, preventive action should take place to prevent our body from suffering from these diseases. This can be done by increasing the human immune status with immunomodulatory agents. Binahong empirically have benefits for wound healing. The purpose of this research was to investigate the immunomodulatory effect of ethanolic extract of binahong leaves. The non-specific modulatory effects of the ethanolic extracts of binahong leaves on the immune systems were measured based on phagocytosis index and phagocytosis capacity. Tests were conducted on strain Balb/C male mice at the age of 6-8 weeks. Mice were administered orally with the extract of binahong leaves (doses of 25, 50, 75 mg/kgBW) for 14 days. The test results with the index parameters and macrophages phagocytosis capacity at doses of 50 and 75 mg/kgBW did not significantly increased when compared with the controls. From these results, we concluded that the ethanolic extract of binahong leaves with a dose of 25, 50 and 75 mg/kgBW cannot significantly the activity of macrophages by phagocytosis index parameters and phagocytosis capacity significantly.
PENGARUH DISREGULASI EPIGENETIK TERHADAP PATOLOGI PENYAKIT ALZHEIMER DAN TARGET TERAPI MELALUI JALUR EPIGENETIK Iradatul Ikhtiari; Marlyn Dian Laksitorini; Nunung Yuniarti
Majalah Farmaseutik Vol 22, No 3 (2026): IN PRESS
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i3.117661

Abstract

The increase in life expectancy is directly proportional to the increasing prevalence of Alzheimer's disease. By 2050, it is estimated that 152 million people will be living with Alzheimer's disease. Alzheimer's disease is a disease caused by progressive neuronal damage, characterized by a decline in cognitive functions such as memory, concentration, and communication impairments. Molecularly, this disease is characterized by the presence of beta-amyloid (Aβ) plaques and tau protein neurofibrillary tangles (NFTs). The pathogenesis of Alzheimer's disease is associated with changes in epigenetic mechanisms, namely changes in DNA expression without involving changes in DNA sequence. Epigenetic mechanisms may contribute to the pathology of Alzheimer's disease through increased activity of the Bace1 and psen1/2 genes, which cleave APP. APP cleavage will predispose to the amyloidogenic pathway, producing toxic Aβ and facilitating tau protein NFTs. The role of epigenetic mechanisms is not limited to the pathology of Alzheimer's disease; several studies have assessed their potential as promising therapeutic targets. Through epigenetic reprogramming, several studies have shown encouraging results. This article reviews the role of epigenetic mechanisms in driving the development of Alzheimer's disease pathology and explores the potential of epigenetic reprogramming as a therapeutic strategy. Through this in-depth approach, it is hoped that this article will open new perspectives on the role of epigenetic mechanisms in Alzheimer's disease pathology and therapeutic targets.
Co-Authors Dika Sotya Sakti Iradatul Ikhtiari Marlyn Dian Laksitorini Perdana Priya Haresmita Subagus Wahyuono