This study aims to analyze the influence of organizational culture and job satisfaction on employee performance at the East Payakumbuh District Office. This is a factor important in supporting the effectiveness of organization service to the public, so that it needs to be supported by a good organizational culture and high levels of job satisfaction. Research This approach quantitative methods with a survey. Population study consists of from all over employee Subdistrict East Payakumbuh, which has 36 people, so that technique taking sample using saturated sampling ( census ). Data collected through distribution questionnaire and analyzed use Partial Least Square-Structural Equation Modeling (PLS-SEM) method with help application SmartPLS 4.0. Research results show that culture organization No influential significant to performance employee with mark coefficient track of 0.190 and p-value of 0.138 (> 0.05), so that hypothesis First No proven. On the contrary, satisfaction Work influential positive and significant to performance employee with mark coefficient track of 0.581 and p-value of 0.000 (< 0.05), so that hypothesis second accepted. Research model own R-Square value of 0.526 which shows that culture organization and satisfaction Work capable explain variation performance employee by 52.6%, while the rest influenced by other factors outside the research model. Based on results study can concluded that satisfaction Work is more factors dominant in increase performance employee compared to culture organizations in the sub-district East Payakumbuh . Therefore that , the effort improvement performance employee should focused on improving satisfaction Work through creation environment conducive work, relationships harmonious work , giving fair reward , and chance development career for employee.