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All Journal Indonesian Journal of Kidney and Hypertension
Fauzar Fauzar
Department of Internal Medicine, Division of Pulmonology, Faculty of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Diagnostic Value of Urinary Kidney Injury Molecule-1 in Diagnosis of Sepsis Associated Acute Kidney Injury Puti Anggun Sari; Drajad Priyono; Harnavi Harun; Deka Viotra; Najirman Najirman; Fauzar Fauzar; Dwitya Elvira; Arina Widya Murni
Indonesian Journal of Kidney and Hypertension Vol 3 No 2 (2026): Volume 3 No. 2 August 2026
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v3i2.263

Abstract

Abstract Background: Sepsis asscociated acute kidney injury (SA-AKI) is common condition that found in sepsis. Due to the lack of creatinine serum, this condition possibly makes therapy delayed. Kidney Injury Molecule-1 (KIM-1) is a a type 1 transmembrane protein with immunoglobulin and mucin domains, which is expressed increased in the proximal tubules of the kidney. Elevated urinary KIM-1 levels are an indicator of AKI. However, previous studies have shown varies results. Objectives: This study aims to determine early diagnosis biomarkers for the presence of AKI in sepsis. Methods: This diagnostic test was conducted at Dr. M. Djamil General Hospital Padang in sepsis patients. The diagnosis of AKI was established based on the 2012 KDIGO criteria. Results: The study involved 94 sepsis patients, only 22,34% (n=21) of them experienced AKI. Serum creatinine levels at admission and within 48 hours of hospitalization were 0,7 (IQR 0,2-1,6) mg/dl and 0,8 (IQR 0,3-2,2m) mg/dl. An urinary KIM-1 level at admission ≥11,74 ng/mL had sensitivity of 44,68%, specificity of 59,57%, positive predictive value of 52,5%, negative predictive value of 51,85%, and accuracy of 52,12% in early diagnosis of AKI in sepsis. Conclusion: Urinary Kidney injury molecule-1 level has poor diagnostic value in diagnosis of AKI in sepsis. Keywords: Sepsis, Kidney injury molecule-1, AKI.
Co-Authors Arina Widya Murni Deka Viotra Drajad Priyono Dwitya Elvira Harun Harnavi Najirman Najirman Puti Anggun Sari