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Khoiroh Itsna Rofiidatul
Master Program in Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Chemistry Medicine & Pharmacology Public Health

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Journal : pharmacoscript

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THE ETHANOL EXTRACT OF Piper sarmentosum Roxb. IMPROVES METABOLIC PARAMETERS IN HIGH-FAT DIET-INDUCED MICE Khoiroh Itsna Rofiidatul; Levita Jutti; Sumiwi Sri Adi
Pharmacoscript Vol. 9 No. 2 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i2.2851

Abstract

A high-fat diet (HFD) is a major risk factor for insulin resistance (IR), obesity, and metabolic disorders. Flavonoids have been reported to attenuate IR and obesity-related metabolic alterations in experimental animal models. As Piper sarmentosum Roxb. leaves are rich in flavonoids and phenolic compounds, this study aimed to evaluate the effects of the ethanol extract of P. sarmentosum leaves (EEPS) on body weight, abdominal circumference, and liver index in HFD-fed mice. Mice were fed an HFD to induce IR and treated with EEPS at different doses. EEPS at 250 mg/kg significantly attenuated HFD-induced increases in body weight gain (12.80%), abdominal circumference (8.44%), and liver index (6.87%) compared with the negative control group (p < 0.05). These findings suggest that EEPS attenuates HFD-induced increases in body weight, abdominal adiposity, and liver index in mice.
Co-Authors Levita Jutti Sumiwi Sri Adi