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All Journal Indonesian Journal of Medical and Pharmaceutical Science
Dwi Monika Ningrum
Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Islam Sultan Agung, Kota Semarang, Indonesia
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Effect of Paracetamol Administration on Clinical Outcome Values in Dengue Hemorrhagic Fever Patients at RSI Sultan Agung Semarang Inesya Febrianing Rizki; Dwi Monika Ningrum; Alycia Raihan Amalia
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 2 (2026)
Publisher : Sultan Agung Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i2.672

Abstract

Background : Dengue Hemorrhagic Fever (DHF) is a viral infection transmitted by the Aedes aegypti mosquito,  wherein high fever can adversely affect a patient's hematological outcomes. This study aimed to evaluate the effect of paracetamol administration on clinical outcome parameters in DHF patients at RSI Sultan Agung Semarang.  Methods: A retrospective, quantitative, observational, and analytical approach with a cross-sectional design was employed. Purposive sampling was used to select 166 medical records of DHF patients containing data on body temperature, hematocrit, platelets, and leukocytes; the data were analyzed using the Kolmogorov-Smirnov and Mann-Whitney tests via SPSS version 27. Results: The majority of patients were male (51.8%) and belonged to the pediatric age group (69.9%). The Mann-Whitney test confirmed a significant effect (p < 0.05) of paracetamol administration on reducing body temperature and regulating hematocrit, platelet, and leukocyte levels. Conclusion: Paracetamol administration significantly influenced the improvement of clinical outcomes, specifically regarding the reduction of body temperature and hematological values in DHF patients.
Co-Authors Alycia Raihan Amalia Inesya Febrianing Rizki