The Effect of Paracetamol Administration on Clinical Outcome Values in Dengue Hemorrhagic Fever Patients at RSI Sultan Agung Semarang

Inesya Febrianing Rizki (Program Studi Pendidikan Profesi Apoteker, Fakultas Farmasi, Universitas Islam Sultan Agung)
Dwi Monika Ningrum (Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Islam Sultan Agung, Kota Semarang, Indonesia)
Alycia Raihan Amalia (Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Islam Sultan Agung, Kota Semarang, Indonesia)

Indonesian Journal of Medical and Pharmaceutical Science
Vol. 5 No. 2 (2026)

Background : Dengue Hemorrhagic Fever (DHF) is a viral infection transmitted by the Aedes aegypti mosquito,  wherein high fever can adversely affect a patient's hematological outcomes. This study aimed to evaluate the effect of paracetamol administration on clinical outcome parameters in DHF patients at RSI Sultan Agung Semarang.  Methods: A retrospective, quantitative, observational, and analytical approach with a cross-sectional design was employed. Purposive sampling was used to select 166 medical records of DHF patients containing data on body temperature, hematocrit, platelets, and leukocytes; the data were analyzed using the Kolmogorov-Smirnov and Mann-Whitney tests via SPSS version 27. Results: The majority of patients were male (51.8%) and belonged to the pediatric age group (69.9%). The Mann-Whitney test confirmed a significant effect (p < 0.05) of paracetamol administration on reducing body temperature and regulating hematocrit, platelet, and leukocyte levels. Conclusion: Paracetamol administration significantly influenced the improvement of clinical outcomes, specifically regarding the reduction of body temperature and hematological values in DHF patients.