<![CDATA[Purpose: This study analyzes the relationship between work motivation, workload, work-related fatigue, and the physical and non-physical work environment and job satisfaction among nurses at Sayang Rakyat Regional General Hospital in South Sulawesi Province, Indonesia. Research Method: This analytical, observational, quantitative study employed a cross-sectional design. A total of 116 respondents were recruited using total sampling. Data were collected using a structured questionnaire and analyzed using the chi-square test and multiple logistic regression with the backward method. Results and Discussion: The reported bivariate results indicate that all five independent variables are associated with job satisfaction. In the final model, work motivation, work fatigue, and the non-physical work environment continued to show an independent association with job satisfaction, whereas workload and the physical work environment did not. Work motivation showed the strongest positive association among the variables retained in the model. Implications: Hospital management needs to strengthen professional recognition, career development, burnout management, adequate recovery time, supportive supervision, communication, and teamwork. Longitudinal studies using validated instruments and objective environmental measurements are needed. Originality: This study integrates psychological factors, job demands, fatigue, and the physical and social environment by distinguishing between the physical and non-physical work environments in the context of a regional hospital.]]>
