Arina Dery Puspitasari
Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia; Department of Pharmacy, Universitas Airlangga Hospital, Surabaya, Indonesia

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Use of Analgesics in Digestive Surgery Patients: A Retrospective Observational Study Budi Suprapti; Sania Rifatul Azizah; Arina Dery Puspitasari; Ismu Nugroho; Zam Zami Jauhari; Mas Agus Milawati Baay
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 2 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i22026.160-172

Abstract

Background: Digestive surgery can cause acute postoperative pain of varying intensity, which, if not treated adequately, can increase morbidity, length of stay, and decrease the quality of life. This study aimed to analyze the analgesic use (type, route, dose, frequency, and duration) in patients who underwent digestive surgery. Methods: A retrospective observational study was conducted at Universitas Airlangga Hospital Surabaya from October 2024 to March 2025. The inclusion criteria were as follows: inpatients aged ≥ 18 years who underwent digestive surgery with one of the five most common diagnoses (cholelithiasis, colorectal cancer, appendicitis, hernias, or hemorrhoids) and received analgesic therapy.  Data were collected from the patients’ medical records, and a descriptive analysis was performed. Results: A total of 142 patients met the inclusion criteria, comprising 48.6% men and 51.4% women, with the majority aged 18-59 years (75.4%). The most common diagnosis was cholelithiasis (45.8% of patients). The analgesic drugs used included opioids (fentanyl, morphine, pethidine, and tramadol), NSAIDs (ketorolac, diclofenac, mefenamic acid, and ibuprofen), non-opioids (metamizole and paracetamol), and adjuvants (diazepam, gabapentin, and amitriptyline). The most commonly used intraoperative analgesic was intravenous fentanyl at a dose of 25-100mcg (83.1%). The most commonly used postoperative analgesic was metamizole 1–3 × 1 g intravenously for 1-8 days (66.2%), and in combination therapy, the most commonly used was paracetamol and ketorolac (18,3%). All patients received postoperative analgesics intravenously, whereas 34.5% received them orally as follow-up therapy. Conclusion: Fentanyl is the preferred option for intraoperative pain relief, and metamizole is commonly used for postoperative pain relief. Another multimodal therapy option is a combination of paracetamol and ketorolac.