JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Vol. 13 No. 2 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

Use of Analgesics in Digestive Surgery Patients: A Retrospective Observational Study

Budi Suprapti (Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Department of Pharmacy, Universitas Airlangga Hospital, Surabaya, Indonesia)

Sania Rifatul Azizah (Pharmacist Professional Education Program, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia)
Arina Dery Puspitasari (Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Department of Pharmacy, Universitas Airlangga Hospital, Surabaya, Indonesia)

Ismu Nugroho (Department of Surgery, Universitas Airlangga Hospital, Surabaya, Indonesia)
Zam Zami Jauhari (Master Program of Clinical Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia)
Mas Agus Milawati Baay (Master Program of Clinical Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia)



Article Info

Publish Date
24 Aug 2026

Abstract

Background: Digestive surgery can cause acute postoperative pain of varying intensity, which, if not treated adequately, can increase morbidity, length of stay, and decrease the quality of life. This study aimed to analyze the analgesic use (type, route, dose, frequency, and duration) in patients who underwent digestive surgery. Methods: A retrospective observational study was conducted at Universitas Airlangga Hospital Surabaya from October 2024 to March 2025. The inclusion criteria were as follows: inpatients aged ≥ 18 years who underwent digestive surgery with one of the five most common diagnoses (cholelithiasis, colorectal cancer, appendicitis, hernias, or hemorrhoids) and received analgesic therapy.  Data were collected from the patients’ medical records, and a descriptive analysis was performed. Results: A total of 142 patients met the inclusion criteria, comprising 48.6% men and 51.4% women, with the majority aged 18-59 years (75.4%). The most common diagnosis was cholelithiasis (45.8% of patients). The analgesic drugs used included opioids (fentanyl, morphine, pethidine, and tramadol), NSAIDs (ketorolac, diclofenac, mefenamic acid, and ibuprofen), non-opioids (metamizole and paracetamol), and adjuvants (diazepam, gabapentin, and amitriptyline). The most commonly used intraoperative analgesic was intravenous fentanyl at a dose of 25-100mcg (83.1%). The most commonly used postoperative analgesic was metamizole 1–3 × 1 g intravenously for 1-8 days (66.2%), and in combination therapy, the most commonly used was paracetamol and ketorolac (18,3%). All patients received postoperative analgesics intravenously, whereas 34.5% received them orally as follow-up therapy. Conclusion: Fentanyl is the preferred option for intraoperative pain relief, and metamizole is commonly used for postoperative pain relief. Another multimodal therapy option is a combination of paracetamol and ketorolac.

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Journal Info

Abbrev

JFIKI

Publisher

Subject

Chemistry Education Health Professions Medicine & Pharmacology Other

Description

Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada ...