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All Journal Medical and Health Journal
Nukman Syafrul Panigoro
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Medicine & Pharmacology

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Evidence Based Case Report: Comparison of Fixed-Dose Combinations Vs Separate Combinations of First-Line Antituberculosis Drugs in Patients With Drug-Sensitive Pulmonary Tuberculosis and Obesity Fajar Wahyu Pribadi; Agian Jeffilano Barinda; Nukman Syafrul Panigoro
Medical and Health Journal Vol 6 No 1 (2026): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.6.1.22052

Abstract

Pulmonary tuberculosis (TB) remains a global health problem, while obesity has the potential to affect the pharmacokinetics of rifampicin and the effectiveness of therapy. Although the WHO recommends a fixed-dose combination (FDC), its effectiveness compared to a single-drug formulation (SDF) in obese patients remains controversial. This Evidence-Based Case Report aims to evaluate the efficacy and safety of FDCs compared to SDFs in obese adult patients with drug-sensitive pulmonary TB. A literature search was conducted in PubMed, Cochrane, and Scopus, yielding four studies that met the criteria (three randomized controlled trials and one cohort study). A critical review revealed mixed results, with some studies supporting the non-inferiority of FDCs, while others indicated a risk of less favorable clinical outcomes. Based on the available evidence, the use of SDFs is more strongly recommended for obese patients with a suboptimal response to FDCs, as this approach has the potential to reduce the risk of underdosing and treatment failure through more optimal monitoring of dosage and clinical response
Co-Authors Agian Jeffilano Barinda Fajar Wahyu Pribadi