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All Journal PROSIDING SEMINAR NASIONAL MANDALA of Health Universa Medicina Jurnal Pengabdian Pada Masyarakat Journal Of Holistic Nursing Science Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Budimas : Jurnal Pengabdian Masyarakat Mandala of Health : A Scientific Journal Medical and Health Journal Journal of Public Health and Pharmacy
Fajar Wahyu Pribadi
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Religion Agriculture, Biological Sciences & Forestry Humanities Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGARUH PEMBERIAN SIMETIDIN TERHADAP KADAR SGOT DAN SGPT TIKUS PUTIH (Rattus norvegicus) YANG DIBERI ANTI TUBERKULOSIS RIFAMPISIN DAN ISONIAZID Siswandari, Wahyu; Pribadi, Fajar Wahyu; Perdini, Eska
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Tuberkulosis (TB) has long been known as an infection diseases, and has been reported to increased.The INH dan Rifampisin are two different drugs that are known tobe the most active drugs, therefore bothdrugs are being used as never ending drugs in curing the TB. Utilization of both INH and rifampisin in acombination to cure the TB patients, however could increase the possibility of hepar lession risk. Thisresearch was aimed to firstly, knowing whether cimetidine could prevent increase of SGOT and SGPT levelsof rats (Rattus norvegicus) given by both drugs INH and rifampisin, and secondly what was the minimumdose of cimetidine that able to prevent the increase of SGOT and SGPT levels. A Completely Random Design(CRD) was applied in this research, 24 male rats (Rattus norvegicus) of the wistar variety were divided into4 different groups. The first group, was only given the INH and rifampisin orally at the doses of 50 mg/Kgbody weight/day, the next groups groups II, III, and IV were also given those two drugs at the same dose, butthe cimetidine was also given at 112,5 , 225, and 450 mg/Kg body weight/day for the 28 days. Consequentlythe SGOT and SGPT levels were measured twice pre and post treatments. The data obtained were analysiedby the paired t test, a one way ANOVA, Post Hoc Tukey’s HSD, Kruskal-Wallis and Mann-Whitney test. Thisresearch result showed that the cimetidine that given following the INH and rifampisin could prevent theincrease of SGOT and SGPT levels. The highest dose of 450 mg/Kg body weight/day that given orally showedhighly significant different from other (p<0,00) in preventing the SGOT and SGPT of treated animals
PENGARUH PEMBERIAN SUSPENSI MENIRAN (Phyllanthus niruri L.) TERHADAP KERUSAKAN HEPAR TIKUS PUTIH YANG DIINDUKSI ANTITUBERKULOSIS RIFAMPISIN DAN ISONIAZID Sulistyoningrum, Evy; Pribadi, Fajar Wahyu
MANDALA of Health Vol 4, No 1 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Tuberculosis treatment required at least two antituberculosis drugs (ATDs) and long term course.Isoniazid (INH) and Rifampicin are the two most active ATDs and were used in whole course of treatment.INH and Rifampicin combination increased risk of hepatotoxixity. Meniran (Phyllanthus niruri L.) containsphyllanthin, active subtance that is believed to have hepatoprotective activity. The aim of this study was toknow the effect of meniran suspension on AST/ALT blood levels and histopathological findings afterinduction of Rifampicin and INH. Twenty five male albino rats (Rattus norvegicus) wistar strain aged twomonths and weighed 150-200 grams were divided into five groups of five each. Positive control (A) wastreated with aquadest, negative control (B) was treated with Rifampicin and INH; one dose meniran (I) waspre-treated with 16,2 mg meniran before ATDs; two dose meniran (II) was pre-treated with 32,4 mg meniranbefore ATDs, three dose meniran (III) was pre-treated with 48,6 mg meniran before ATDs. The drugs wereadministered orally for 28 days. Blood samples for ALT/AST levels and histopathology sample were taken atthe end of study. One way ANOVA, post hoc and linear regression were used for data analysis. There wassignificant mean difference for ALT levels (p=0,000) but not for AST level (p> 0,05). Increasing dose ofmeniran decreased serum level of ALT (r=-0,539). Vacuolar degeneration, necrosis and portal triadleucocytes infiltration were most common in negative control groups, while these changes were reduced inmeniran-treated groups. We can conclude that meniran pretreatment reduces INH-rifampicin-inducedhepatotoxicity.
Pengaruh Pemberian Kafein Selama Kehamilan Terhadap Berat Lahir Dan Gambaran Histologis Uterus Dan Plasenta Tikus Putih (Rattus Norvegicus) Sulistyoningrum, Evy; Pribadi, Fajar Wahyu
Journal Of Holistic Nursing Science Vol 1 No 2 (2014)
Publisher : Universitas Muhammadiyah Magelang

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Abstract

  Kafein sering digunakan secara luas oleh masyarakat baik untuk konsumsi harian maupun pengobatan. Kafein dapat melewati sawar plasenta, masuk ke fetus dalam kadar yang seimbang dengan kadar maternal.  Tujuan dari penelitian ini adalah untuk mengetahui efek pemberian kafein selama kehamilan terhadap berat lahir fetus serta gambaran histologis uterus dan plasenta. Penelitian ini adalah eksperimen dengan menggunakan  tigapuluh ekor tikus putih galur Sprague-Dawley hamil, berumur sekitar 2 bulan dan berat 150-200 gram dibagi dalam enam kelompok, diobservasi sampai kelahiran kemudian dilakukan penimbangan berat lahir fetus dan pengamatan gambaran histologis uterus dan plasenta.Pada penelitian ini didapatkan hasil bahwa   pemberian  kafein selama kehamilan menurunkan rerata berat lahir fetus dan memberikan gambaran oedema, perdarahan dan peradangan pada jaringan uterus dan plasenta 
Pengaruh Pemberian Kafein Selama Kehamilan Terhadap Berat Lahir Dan Gambaran Histologis Uterus Dan Plasenta Tikus Putih (Rattus Norvegicus) Sulistyoningrum, Evy; Pribadi, Fajar Wahyu
Journal of Holistic Nursing Science Vol 1 No 2 (2014)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (42.535 KB)

Abstract

Kafein sering digunakan secara luas oleh masyarakat baik untuk konsumsi harian maupun pengobatan. Kafein dapat melewati sawar plasenta, masuk ke fetus dalam kadar yang seimbang dengan kadar maternal. Tujuan dari penelitian ini adalah untuk mengetahui efek pemberian kafein selama kehamilan terhadap berat lahir fetus serta gambaran histologis uterus dan plasenta. Penelitian ini adalah eksperimen dengan menggunakan tigapuluh ekor tikus putih galur Sprague-Dawley hamil, berumur sekitar 2 bulan dan berat 150-200 gram dibagi dalam enam kelompok, diobservasi sampai kelahiran kemudian dilakukan penimbangan berat lahir fetus dan pengamatan gambaran histologis uterus dan plasenta.Pada penelitian ini didapatkan hasil bahwa pemberian kafein selama kehamilan menurunkan rerata berat lahir fetus dan memberikan gambaran oedema, perdarahan dan peradangan pada jaringan uterus dan plasenta
EFFECT OF ETHANOL EXTRACT OF SNAKE FRUIT‟S PEEL EFFECT ON URIC ACID AND CRP Pribadi, Fajar Wahyu; -, Setiawati; Ati, Viva Ratih Bening; Widiartini, Catharina; Panuntun, Hilmi Puguh
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2017: Proceeding International Seminar of Occupational Health and Medical Sciences (I-SOCMED) 2017 â
Publisher : Universitas Muhammadiyah Semarang

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Abstract

Unhealthy diet that consisted of high purine, derived from protein, had caused an increasing hyperuricemia-related disease in community. Anti-oxidant activity of snake fruit‟s peel had antihyperuricemia effect due to the flavonoid content. This study aimed to investigate the effect of ethanol extract of snake fruit‟s peel in reducing uric acid serum & C-Reactive Protein (CRP) level and to find outthe most effective dosage of the activity. The rats were grouped into 6 groups (negative control, positive control, Allopurinol, dosage I (105 mg/kgbw extract), dosage II (210 mg/kgbw) and dosage III (420 mg/kgbw). All, except negative control groups were fed by standard diet pellet mixed with 20 mg/day goat brain for 15 days. Serum uric acid and CRP level of all groups was measured on day 0,9 and 16. The result showed that the uric acid serum level of extract groups was lower than control groups and therewas CRP reduction in extract groups. The most effective dosage for reducing serum uric acid level was 420 mg/kgbw. Keyword : snake fruit‟s peel, uric acid serum, C-Reactive Protein (CRP)
Peningkatan Penggunaan Antibiotik Secara Bijak Melalui Intervensi Alih Pengetahuan Untuk Merubah Persepsi Masyarakat di Kabupaten Banyumas Dwi Utami Anjarwati; Fajar Wahyu Pribadi; Idsap Peramiarti
Jurnal Pengabdian Pada Masyarakat Vol 2 No 2 (2017)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (751.269 KB) | DOI: 10.30653/002.201722.24

Abstract

IMPROVED USE OF ANTIBIOTIC BY USING TRANSFER OF KNOWLEDGE INTERVENTIONS TO CHANGE THE COMMUNITY PERCEPTION IN BANYUMAS DISTRICT. The use of antibiotics without indication by the medical community and the community became the trigger factor of increasing the incidence of antibiotic resistance in Indonesia. Meanwhile by 20150 antibiotic resistance is predictedto be the leading cause of death in the world. Community devotion was aimed at improving the understanding of society so that that is a change of perception about the use of antibiotic wisely. The target respondents of devotion consists of member of the family welfare empowerment group (PKK). A seriaes of activities undertaken were pre and post test to measure respondents' understanding of antibiotic use before and after intervention in the transfer of knowledge. The questionnaire used previously tested its validity by Pearson product moment test and its reliability by Alpha-Cronbach. The Sharpening of material obtained in knowledge transfer was done with role play and discussion. The result of T test analysis to score of quesionnaire before and after knowledge transfer showed significant p value (p = 0,049). The conclusion was that the transfer of knowledge can change the perception of PKK members about the wise use of antibiotics.
The protective effect of celery ethanol extract on oxidative stress in chronic kidney disease rat model Afifah Afifah; Fajar Wahyu Pribadi; Aulia Salsabiela; Dimo Hari Anggara; Zahra Muthmainnah Komara; Robby Al Fauzy
Universa Medicina Vol. 41 No. 2 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.114-120

Abstract

BackgroundChronic kidney disease (CKD) is a serious health problem in which oxidative stress plays an important role. Oxidative stress is an imbalance of reactive oxygen species (ROS) production and antioxidant defense, where antioxidants have the potential to inhibit CKD progression. Celery contains several substances that have an antioxidant effect. This study aimed to evaluate the administration of celery ethanol extract in the prevention of the progressive damage in CKD caused by oxidative stress in male rats. MethodsTwenty male Sprague-Dawley rats were randomly divided into 5 groups: sham operation (SO, n=4), subtotal nephrectomy (SN, n=4), SN+celery ethanol extract 200 mg/kg BW (SN+S1, n=4), SN+celery ethanol extract 250 mg/kg BW (SN+S2, n=4), SN+celery ethanol extract 300 mg/kg BW (SN+S3, n=4). The celery ethanol extract was given for 14 days before induction of CKD and 21 days after induction of the CKD rat model. Serum creatinine, malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were examined in this study. Data were analyzed by One way ANOVA followed by LSD test for creatinine, MDA, SOD, and Kruskal Wallis test for GSH. ResultsThere were significant between-group differences in serum creatinine, SOD, and MDA (p<0.05), but not in GSH (p>0.05). The administration of celery ethanol extract at 250 mg/kg BW was the most effective in preventing an increase in MDA and a decrease in SOD and GSH. ConclusionCelery ethanol extract has the potential to prevent oxidative stress in the CKD rat model.
THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) AS ANTIPSORIATIC AND TO LYMPHOCYTES COUNT OF SKIN TISSUE IN PSORIASIS MICE MODEL Putri Nur'afni Sa'adah; Thianti Sylviningrum; Dody Novrial; Fajar Wahyu Pribadi; Wahyu Dwi Kusdaryanto; Muhamad Salman Fareza
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (538.872 KB) | DOI: 10.20884/1.mandala.2021.14.1.4958

Abstract

ABSTRACT Psoriasis is a chronic skin disease in form of papule-shaped lesion and erythematous plaques with thick white scales. The pathogenesis of psoriasis involves IL-23/Th-17 cytokine pathway that contributes the activation of T-lymphocytes and proinflammatory cytokines. Treatment of psoriasis using methotrexate has inhibitory effect of the synthesis of nucleic acid towards T-lymphocytes and keratinocytes. Ciplukan (Physalis angulata L.) has anti-inflammatory potential effect which contains steroid, flavonoid, alkaloid, and physalin that may inhibit lymphocyte activation and proinflammatory cytokine production. The study is used the method of experimental study with post test only with control group design. Thirty five female mices were divided into 7 groups. The parameters of this study is anti-psoriatic (PASI and Baker’s score) and lymphocytes count in psoriasis mice model. The results of Kruskal-Wallis, PASI and Baker’s score showed that p=0,001 (p<0,05) and the result of lymphocytes count using One Way ANOVA showed that p=0,001 (p<0,05). The 800 mg/kgBW dose of ciplukan extract showed the largest decrease on PASI score and lymphocytes count, and the 1200 mg/kgBW dose one showed the largest decrease on the Baker’s score. The present of the 800 mg/kgBW dose of ciplukan extract gives the most optimal effect in reducing PASI score and skin tissue lymphocytes count in psoriasis mice model that were not significantly different with the treatment control group, while 1200 mg/kgBW dose one gives the most optimal effect in reducing Baker’s score that were significantly different with the treatment control group. Keywords: Ciplukan extract, lymphocytes, methotrexate, Physalis angulata L
EFFECT OF GIVING GARLIC ON URIC ACID LEVELS OF HYPERURISEMIC WHITE RATS (Rattus norvegicus) Fajar Wahyu Pribadi; Afifah Afifah; Gita Nawangtantrini
Medical and Health Journal Vol 2 No 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.031 KB) | DOI: 10.20884/1.mhj.2023.2.2.8340

Abstract

Hiperurisemia adalah kondisi dimana kadar asam urat dalam tubuh melebihi batas normal akibat peningkatan sintesis purin yang berlebih dalam tubuh karena pola makan tidak sehat, proses pengeluaran asam urat dari dalam tubuh mengalami gangguan atau kombinasi dari keduanya. Bawang hitam mengandung s-alyl cistein (SAC), tetrahydro-β-carbolines, alkaloid, dan flavonoid yang diduga menghambat kerja dari enzim xanthine oksidase sehingga dapat menurunkan asam urat. Tujuan jangka pendek penelitian ini untuk mengetahui efek bawang hitam terhadap kadar asam urat tikus putih hiperurisemik. Tujuan jangka panjang yang ingin dicapai yaitu pemanfaatan bawang hitam untuk pencegahan dan atau mengatasi dampak negatif hiperurisemia. Tikus dikelompokkan menjadi lima kelompok yaitu kontrol control positif (A), kelompok allopurinol (B), kelompok bawang hitam dosis 240mg (C), 480mg (D) dan 960mg (E). Induksi hiperurisemia dilakukan dengan injeksi kalium oksonat dan penambahan otak sapi selama 14 hari, dilanjutkan bersama dengan pemberian perlakuan. Hasil rata-rata asam urat pada masing- masing kelompok adalah A: 15,02 ± 0.71, B: 6,45 ± 0,13, C: 8,46 ± 0,12, D: 7,64 ± 0,14, E: 7,55 ± 0,55. Data dianalisis menggunakan One Way ANOVA dilanjutkan Post Hoc LSD. Kesimpulan pemberian bawang hitam berbagai dosis dapat menurunkan kadar asam urat pada tikus hiperurisemia.
The Relationship Between Anatomy Identification Test Scores and The Suitability in V/A/R/K Modality Usage Between Study Habit and Learning Style Widiartini, Catharina; Ferine, Miko; Pribadi, Fajar Wahyu
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 13, No 2 (2024): June
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpki.92758

Abstract

Background: Mastery of Anatomy is essential to base learning in Medicine. However, the Anatomy identification test scores are often less than satisfactory. This problem could be caused by different usage of sensory modalities which were visual, aural, read/write, and kinaesthetic (V/A/R/K) between one’s study habit and his/her learning style. This study aimed to determine the relationship between Anatomy identification test scores and the suitability in V/A/R/K modality usage between study habits and learning styles.Method: This was an observational study of 103 first year students of the Faculty of Medicine Unsoed who were selected using total sampling, taking into account the inclusion criteria in the form of complete data availability for the three variables. Univariate statistical analyses were conducted for each variable as well as the suitability between study habits and learning style based on determined criteria. Relationship between Anatomy identification test scores and the suitability between V/A/R/K study habits and learning styles was analyzed using the Mann-Whitney test.Results: Most students had quadmodal learning style (27.2%), but unimodal visual study habit (21.4%). Most (64.1%) students had no suitability between study habits and learning styles, with the test score average was not significantly lower (p = 0.228) than those with suitability. Conclusion: There is no significant relationship between Anatomy identification test scores and the suitability between study habits and learning styles. Students may reflect on the result to modify their learning process further. Institution can provide opportunities for students with various characteristics to develop study habits that suit their learning styles.
Co-Authors Afifah Afifah Alice Yuniaty Aulia Salsabiela Dimo Hari Anggara Dody Novrial Dwi Utami Anjarwati Eliada Herwiyanti Eska Perdini, Eska Evy Sulistyoningrum Fareza, Muhamad Salman Gita Nawangtantrini Idsap Peramiarti Miko Ferine Muhammad Afif Nawangtantrini, Gita Panuntun, Hilmi Puguh Putri Nur'afni Sa'adah Riski Fatah, Muhammad Robby Al Fauzy Setiawati - Thianti Sylviningrum Viva Ratih Bening Ati Wahyu Dwi Kusdaryanto Wahyu Siswandari Wahyudin Wahyudin Widiartini, Catharina Zahra Muthmainnah Komara Zainuddin Zainuddin