<![CDATA[Background: Patients using mechanical ventilators in the Intensive Care Unit (ICU) are at risk of impaired oxygenation due to ventilation-perfusion imbalance. One nursing intervention that can improve oxygenation is the semi Fowler position. This position can increase lung expansion and improve gas exchange, thereby increasing oxygen saturation. Objective: This study aimed to determine the effect of the semi Fowler position on oxygen saturation in patients with mechanical ventilators in the ICU. Methods: This study used a quantitative method with a pre-experimental one group pretest-posttest design. The study was conducted in the ICU Room of RSUD drg. Clara Gobel Boalemo Gorontalo from April to May 2026. The sample consisted of 20 respondents selected using purposive sampling technique. The intervention was the semi Fowler position with head elevation of 30°–45° for 30 minutes. Oxygen saturation was measured using a pulse oximeter before and after the intervention. Data were analyzed using the Wilcoxon Signed Rank Test with a significance level of α = 0.05. Results: The mean oxygen saturation before intervention was 90.90% and increased to 98.05% after the semi Fowler position intervention. Statistical analysis showed a p-value of 0.000 (p < 0.05), indicating a significant effect of the semi Fowler position on increasing oxygen saturation in patients using mechanical ventilators. Conclusion: The semi Fowler position is effective in improving oxygen saturation in mechanically ventilated patients in the ICU and can be used as a simple, safe, and evidence-based independent nursing intervention.]]>
