The efficacy of nurses is a vital indicator of healthcare service quality and patient safety. Nurses frequently face time limitations, job stress, and burnout, which can impair their ability to provide quality care. This study aims to investigate the effects of time management, occupational stress, and burnout on the performance of nurses in Cirebon City. This study utilized a quantitative explanatory design. The population consisted of 1,505 nurses employed in hospitals and healthcare facilities in Cirebon City. The minimum sample size was 316 respondents, determined using the Slovin formula, whereas 350 valid responses were analyzed. Data were collected by a structured questionnaire utilizing a five-point Likert scale and analyzed with SPSS, including descriptive statistics, validity and reliability evaluations, classical assumption tests, multiple linear regression, t-tests, F-tests, and determination coefficients. The findings indicated that time management positively and significantly influenced nurse performance, whereas work stress and burnout negatively and significantly impacted it. The concurrent assessment indicated that time management, work-related stress, and burnout collectively impacted nurse performance. The adjusted R-squared value of 0.207 signifies that 20.7% of nurse performance is elucidated by the three factors. This study concludes that improving nurse performance requires effective time management, stress control, and burnout prevention strategies. The findings provide practical implications for health care managers to strengthen workload management, supportive supervision, and psychological well-being programs for nurses.