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All Journal Majalah Patologi Indonesia
Elisa Laura Oktrinita Sitohang
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Health Professions Public Health

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H3K27me3 Expression has Association with Histological Grade of Meningioma Elisa Laura Oktrinita Sitohang; Ni Putu Sriwidyani; Ni Made Mahastuti; Putu Erika Paskarani; I Made Gotra; I Made Muliarta
Majalah Patologi Indonesia Vol. 35 No. 2, Mei 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i2.671

Abstract

Background Meningioma is the most common primary central nervous system tumor. It has various histological patterns, locations, and grades, and posing challenges in therapy and prognosis. It has a complex tumorigenesis and H3K27me3 epigenetic changes is one of the factors that play a role in meningioma tumorigenesis. This study aims to determine the correlation of H3K27me3 expression with clinicopathological factors in meningioma. Method This study was an analytical observational study with a cross-sectional study involving 73 cases of meningioma at Prof. Dr. I.G.N.G. Ngoerah Hospital Denpasar, consisting 36 grade 1 cases, 31 grade 2 cases, and 6 grade 3 cases. H3K27me3 expression was evaluated by immunohistochemical staining and its expression was classified into retain and loss. A chi-square test was done to analyze the relationship between H3K27me3 expression with age, gender, location, and histological grade of meningioma. Significance was determined at p<0.05. Result In this study, 5 cases (6.8%) showed H3K27me3 loss and were found in 9.7% of grade 2 cases and 33.3% grade 3 cases. Bivariate analysis showed a significant relationship between grade and H3K27me3 expression (p=0.018). There was no significant association between H3K27me3 expression and age, gender, and location. Conclusion The expression of H3K27me3 is associated with the grade of meningioma. It provides additional prognostic information in conjunction with other clinicopathological parameters.
The Association of BCL2 Expression with Proliferation Index Ki67 and Clinicopathology Aspect of Diffuse Large B-Cell Lymphoma Ni Made Mahastuti; Cheryl Nini; Elisa Laura Oktrinita Sitohang
Majalah Patologi Indonesia Vol. 35 No. 2, Mei 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i2.679

Abstract

Background Diffuse Large B-cell Lymphoma (DLBCL) is the most common lymphoma. It has various histological patterns, grades, and poses challenges in therapy and prognosis The prognosis of DLBCL is determined by several factors, including immunophenotyping and genetics involving the BCL2 protein This study aims to determine the correlation between BCL2 expression and clinicopathological factors including age, gender, histopathological variants, and proliferation index Ki67 in DLBCL. Method This study was an analytical observational study with a cross-sectional study involving 50 cases of DLBCL at Prof. Dr. I.G.N.G. Ngoerah Hospital Denpasar. BCL2 expression was evaluated by immunohistochemical staining and its expression was classified into positive and negative. A chi-square test was done to analyze the relationship between BCL2 expression with age, gender, morphology variant, and proliferation index Ki67 of DLBCL. Significance was determined at p<0.05. Result In this study, a total of 25 (75.8%) out of 33 cases of male patients had positive BCL2 expression, in contrast to female patient samples who showed more negative BCL2 examples. A total of 27 cases (69.2%) of all cases with high Ki67 index proliferation showed BCL2 positive. Bivariate analysis showed a significant relationship between gender (p=0.005) and Ki67 proliferation index (p=0.047) with BCL2 expression. There was no significant association between BCL2 expression with age and morphology variant. Conclusion There is a significant association between BCL2 with Ki67 expression and the clinicopathological aspect of gender in DLBCL. It provides additional prognostic information in conjunction with other clinicopathological parameters. It also can be considered to use Ki67 as one of the indicators of prognosis factors in DLBCL cases and considered as a substitute for BCL2 as one of the markers of DLBCL progressivity at Prof. Dr.I.G.N.G Ngoerah Hospital.
Co-Authors Cheryl Nini I Made Gotra I MADE MULIARTA . Ni Made Mahastuti Ni Made Mahastuti Ni Putu Sriwidyani Putu Erika Paskarani