Background: Women with polycystic ovary syndrome (PCOS) face a wide range of physical, psychological, and social challenges that may negatively affect their psychological well-being. Previous studies have identified various psychosocial and demographic factors associated with the psychological well-being of women with PCOS; however, findings regarding these associations remain inconsistent. Purpose: This study examined the associations between potentially modifiable factors, including religiosity, social support, and body mass index (BMI), and psychological well-being among women with PCOS.Methods: This study employed an analytical cross-sectional design. A total of 106 respondents were recruited using convenience sampling from the “PCOS Fighter Indonesia” Instagram community. Data were collected using a demographic questionnaire, a religiosity scale, the Multidimensional Scale of Perceived Social Support, and a psychological well-being questionnaire. Bivariate analysis was performed using the Fisher-Freeman-Halton exact test due to small expected cell counts. Multivariable binary logistic regression was performed to identify factors independently associated with psychological well-being.Results: Social support was significantly associated with psychological well-being (p = 0.029), whereas BMI (p = 0.076) and religiosity (p = 0.815) were not. In the final multivariable model, participants with low social support had higher odds of poor psychological well-being than those with high social support (OR = 9.50, 95% CI [1.32, 68.31], p = .025).Conclusion: Social support was the most dominant modifiable factor associated with psychological well-being among women with PCOS. Nurses should provide supportive and community-based interventions that focus on strengthening social support to improve psychological well-being among women with PCOS.