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All Journal Eksakta : Berkala Ilmiah Bidang MIPA
Gita Dwi Prasasty
Department of Parasitology, Department of Biomedical Science, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Mechanical Engineering

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Role of Interleukin-10 Promoter Gene Polymorphisms in Susceptibility to Systemic Lupus Erythematosus: Systematic Review Desi Oktariana; Ade Rizki Putri Ratih; Phey Liana; Kemas Ya’kub Rahadiyanto; Ririn Eviningtyas; Gita Dwi Prasasty; Yuniza Yuniza; Hafizzanovian Hafizzanovian; Aseptianova Aseptianova
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 04 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss04/725

Abstract

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation that predominantly affects women of reproductive age. Genetic factors, particularly polymorphisms within the interleukin-10 (IL-10) promoter region, have been implicated in disease susceptibility through their influence on cytokine expression and immune regulation. This systematic review aimed to evaluate the association between IL-10 promoter polymorphisms and SLE susceptibility across different populations. A systematic literature search was conducted according to PRISMA guidelines using Google Scholar, PubMed, ScienceDirect, SagePub, and Wiley Online Library for studies published between 2005 and 2025. Eligible case-control studies investigating IL-10 promoter polymorphisms in SLE were included. Of 82 records identified, 12 studies met the eligibility criteria, comprising 2,462 patients with SLE and 3,274 healthy controls. Most studies reported significant associations between SLE susceptibility and the IL-10 promoter polymorphisms −1082A/G, −819C/T, and −592C/A. The GCC haplotype was the most consistently reported risk haplotype and was frequently associated with increased IL-10 expression and greater susceptibility to SLE. Overall, current evidence supports the contribution of IL-10 promoter polymorphisms to genetic susceptibility to SLE across diverse populations.
Co-Authors Ade Rizki Putri Ratih Aseptianova Aseptianova Desi Oktariana Hafizzanovian Hafizzanovian Kemas Ya’kub Rahadiyanto Phey Liana Ririn Eviningtyas Yuniza Yuniza