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All Journal Indonesian Journal of Medical and Pharmaceutical Science
Tri Diana Puspita Rini
Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Islam Sultan Agung, Semarang Kota, 50112, Indonesia
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Analisis Jejaring Farmakologi Daun Alpukat Sebagai Antihipertensi Tri Diana Puspita Rini; Wawan Sahrawi
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 2 (2026)
Publisher : Sultan Agung Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i2.494

Abstract

Background: Hypertension is a common disease defined simply as persistently elevated arterial blood pressure. Measurements include systolic and diastolic blood pressure. Systolic blood pressure is the maximum blood pressure in large arteries when the heart muscle contracts to push blood throughout the body. In contrast, diastolic blood pressure is the lowest pressure in large arteries during relaxation of the heart muscle. Methods: This study was analyzed using the KNApSAcK, PubChem, Swess ADME, GeneCards, Swes Target Prediction, Venny Analysis, String, Cytoscape Analysis, GO Function Analysis, and KEGG Pathway Enrichment databases. Results: The screening indicated that 41 compounds fulfilled the Lipinski Rule of Five parameters found to meet the Lipinski Rules of Five requirements. Analysis using GeneCards identified 13,546 proteins related to hypertension. Of these, 430 proteins were predicted to interact with Persea americana secondary metabolites. KEGG analysis showed that Persea americana secondary metabolites are associated with several hypertension disease pathways. Analysis using the MCC, Degree, Closeness, and Betweenness algorithms showed that there were ten main target proteins related to hypertension. Conclusion: Secondary metabolites of Persea americana have the potential to be used as antihypertensive agents.
Co-Authors Wawan Sahrawi