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All Journal Indonesian Journal of Pharmaceutical and Clinical Research
Nisa Aldila
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Cytotoxic and Antibacterial Activity of Hexana Plants Extract Scurrula ferruginea Jack Danser (Coffee Parasite) Rosnani Nasution; Nisa Aldila; Muhammad Bahi; Marianne Marianne
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 9 No. 01 (2026): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v9i01.25277

Abstract

Cytotoxic compounds are substances that can inhibit the growth of cancer cells, whereas antibacterial compounds inhibit microbial growth. This study was conducted to evaluate the cytotoxic and antibacterial effects of Scurrula ferruginea Jack Danser. The cytotoxic activity was assessed against Artemia salina larvae using the Brine Shrimp Lethality Test (BSLT), while antibacterial activity was evaluated against P. acnes using the agar diffusion method. The results showed that S. ferruginea exhibited cytotoxic activity against A. salina larvae. The tested concentrations were 50, 100, 250, 500, and 1000 ppm. The LC₅₀ value of S. ferruginea against A. salina larvae was 19.49 ppm. The antibacterial activity of the n-hexane extract of S. ferruginea, tested at concentrations of 0.5%, 2%, 5%, 7.5%, and 12%, showed no inhibitory effect against P. acnes (positive control inhibition zone: 20.66 mm). GC-MS characterization revealed that the n-hexane extract of S. ferruginea contained 14 compounds, with lupeyl acetate (44.99%) identified as the dominant compound.
Co-Authors Marianne Marianne Muhammad Bahi Rosnani Nasution