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All Journal Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Natural Journal Of Carbazon
Marianne Marianne
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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Antidiabetic Activity of Leaves Ethanol Extract Chromolaena odorata (L.) R.M. King on Induced Male Mice with Alloxan Monohydrate Marianne Marianne; Dwi Lestari; Elin Yulinah Sukandar; Neng Fisheri Kurniati; Rosnani Nasution
Jurnal Natural Volume 14, Number 1, March 2014
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (79.312 KB)

Abstract

Chromolaena odorata or Tekelan has been used traditionally to cope with diabetes mellitus, but the scientific evidence as antidiabetic agent has not been previously reported. Therefore, it is necessary to test the antidiabetic activity using ethanol extract of the tekelan leaves in male mice induced by alloxan. Mice were induced intravenously by alloxan dose of 55 mg/kg bw. After 7 days, mice were diabetic ( KGD 200 mg/dL ) and were grouped into 6 groups: negative control group (only treated with CMC - Na) , positive control group (glibenclamide 0.45 mg/kg bw) and the 4 other groups were given ethanol extract of Tekelan leaves at doses of 5 , 25 , 125 and 250 mg/kg bw. Dosage administered for 28 days and blood glucose levels was checked every 7 days using a glucotest. Data were analyzed by one-way analysis of variation at 95% confidence level. Ethanol extract of tekelan’s leaves  at doses of 5 , 25 , 125 and 250 mg/kg bw can lower blood levels  from day 7 to day 28 and was significantly different compared to the negative control group ( p 0.05). Ethanol extract of tekelan’s leaves at doses of 5 , 25 , 125 and 250 mg/kg bw showed antidiabetic activity in alloxan-induced mice.
Antibacterial Activity Of Neem (Azadirachta indica A. Juss) Essential Oil Obtained By The Enfleuration Method Against Propionibacterium acnes Bacteria In Liquid Soap Formula Rosnani Nasution; Muhammad Bahi; Marianne Marianne; Dara Hadisah
Journal of Carbazon Vol 3, No 1 (2025): June 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jocarbazon.v3i1.46643

Abstract

This research was conducted to determine the antibacterial activity of Azadirachta indica flower essential oil and its liquid soap formulation against P. acnes bacteria and to determine the quality of the liquid soap formulation. The essential oil of A. indica flower was obtained by the enfleuration method, the yield was a concentrated yellow essential oil with a yield of 2.151%, a density of 0.892 g/mL, solubility in ethanol 90%, 1:1, clear; and a refractive index of 1.435 which complies with the Indonesian National Standard (SNI). Furthermore, essential oils are formulated into liquid soap preparations and tested for physical quality and antibacterial activity. The liquid soap formulation had a distinctive odor of A. indica flowers, and homogen. The antibacterial activity against P. acnes bacteria, was the inhibitory value of A. indica flower liquid soap was higher than A. indica flower essential oil with the highest liquid soap inhibition power of 52%, while the inhibitory power of essential oil was 51% with each concentration of 2.5%, which was compared to its positive control, namely chloramphenicol. The quality testing of liquid soap is accordance with SNI 06-4085-1996, pH values ranging from 8.48 9.67 meet SNI (8-11), viscosity values ranging from 1504.4 cP 2369.7 cP meet SNI (400-4000 cPs), and foam height values ranging from 7.1 cm 8.3 cm. The results of the GC MS analysis of A. indica essential oil showed that the dominant compound was -Copaene (15.84%).
Cytotoxic and Antibacterial Activity of Hexana Plants Extract Scurrula ferruginea Jack Danser (Coffee Parasite) Rosnani Nasution; Nisa Aldila; Muhammad Bahi; Marianne Marianne
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 9 No. 01 (2026): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v9i01.25277

Abstract

Cytotoxic compounds are substances that can inhibit the growth of cancer cells, whereas antibacterial compounds inhibit microbial growth. This study was conducted to evaluate the cytotoxic and antibacterial effects of Scurrula ferruginea Jack Danser. The cytotoxic activity was assessed against Artemia salina larvae using the Brine Shrimp Lethality Test (BSLT), while antibacterial activity was evaluated against P. acnes using the agar diffusion method. The results showed that S. ferruginea exhibited cytotoxic activity against A. salina larvae. The tested concentrations were 50, 100, 250, 500, and 1000 ppm. The LC₅₀ value of S. ferruginea against A. salina larvae was 19.49 ppm. The antibacterial activity of the n-hexane extract of S. ferruginea, tested at concentrations of 0.5%, 2%, 5%, 7.5%, and 12%, showed no inhibitory effect against P. acnes (positive control inhibition zone: 20.66 mm). GC-MS characterization revealed that the n-hexane extract of S. ferruginea contained 14 compounds, with lupeyl acetate (44.99%) identified as the dominant compound.
Co-Authors Dara Hadisah Dwi Lestari Elin Yulinah Muhammad Bahi Muhammad Bahi Neng Fisheri Kurniati Neng Fisheri Kurniati Nisa Aldila Rosnani Nasution Rosnani Nasution