Rikko Hudyono
Sultan Agung Islamic University

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Influence of Bisphosphonates on Implant and Peri-Implant Health: A Systematic Review and Meta Analysis Rikko Hudyono; Louis Krisna Wardhana; Adisty Restu Poetri; Taufan Bramantoro
Odonto : Dental Journal Vol 13, No 2 (2026): August 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.2.150-161

Abstract

Introduction: Bisphosphonates are widely prescribed for osteoporosis, raising concerns regarding their potential impact on dental implant survival. This systematic review and meta-analysis evaluated the association between bisphosphonate therapy and dental implant failure. Material and Methods: Following PRISMA guidelines and registered in PROSPERO (ID: 1136620), electronic searches of ScienceDirect, EBSCOhost, PubMed, MDPI, and Google Scholar were performed up to September 2025. Observational cohort studies comparing dental implant outcomes in bisphosphonate-exposed and non-exposed patient were included. Two reviewers performed data extraction and risk-of-bias assessment using the ROBINS-I. Pooled risk ratios (RRs) were calculated. Results: Six studies comprising 2,196 participants and 86 implant failures were included. Bisphosphonate exposure was associated with a significantly increased risk of implant failure (RR = 2.35; 95% CI, 1.24–4.44). with no heterogeneity (I² = 0%). Discussion: Despite the elevated relative risk, implant failure remained infrequent, resulting in a small absolute risk increase. The certainty of evidence was rated as moderate. Conclusion: Implant therapy should not be routinely avoided in bisphosphonate-treated patients, and individualized risk assessment is recommended. Further prospective studies are needed to clarify causality and patient-level risk modifiers.
Influence of Bisphosphonates on Implant and Peri-Implant Health: A Systematic Review and Meta Analysis Rikko Hudyono; Louis Krisna Wardhana; Adisty Restu Poetri; Taufan Bramantoro
Odonto : Dental Journal Vol 13, No 2 (2026): August 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.2.150-161

Abstract

Introduction: Bisphosphonates are widely prescribed for osteoporosis, raising concerns regarding their potential impact on dental implant survival. This systematic review and meta-analysis evaluated the association between bisphosphonate therapy and dental implant failure. Material and Methods: Following PRISMA guidelines and registered in PROSPERO (ID: 1136620), electronic searches of ScienceDirect, EBSCOhost, PubMed, MDPI, and Google Scholar were performed up to September 2025. Observational cohort studies comparing dental implant outcomes in bisphosphonate-exposed and non-exposed patient were included. Two reviewers performed data extraction and risk-of-bias assessment using the ROBINS-I. Pooled risk ratios (RRs) were calculated. Results: Six studies comprising 2,196 participants and 86 implant failures were included. Bisphosphonate exposure was associated with a significantly increased risk of implant failure (RR = 2.35; 95% CI, 1.24–4.44). with no heterogeneity (I² = 0%). Discussion: Despite the elevated relative risk, implant failure remained infrequent, resulting in a small absolute risk increase. The certainty of evidence was rated as moderate. Conclusion: Implant therapy should not be routinely avoided in bisphosphonate-treated patients, and individualized risk assessment is recommended. Further prospective studies are needed to clarify causality and patient-level risk modifiers.
KNIFE-EDGE MODIFIED SUBGINGIVAL CROWN PREPARATION: DENTAL PREPARATION ACCORDING TO BIOLOGICAL PRINCIPLES Rikko Hudyono; Helmi Fathurrahman; Nafisah Elok; Welly Anggarani; Rama Putranto
Odonto : Dental Journal Vol. 11 No. 2 (2024): December 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.2.305-316

Abstract

Fixed bridge and crown restorations are widely utilized in dental practice. The utilization of bridge as a substitute for implants is prevalent in several contexts. The crown preparation procedure has a crucial role in determining the long-term periodontal tissue health. Under-preparation frequently manifests in many clinical circumstances, resulting in the thickening of the prosthetic crown in the cervical region. The accumulation of plaque in subgingival preparations is an often seen issue. Given the progressive advancements in material technology and manufacturing procedures, it is imperative to critically evaluate the continued suitability of chamfer and shoulder preparation techniques in contemporary practice. This is particularly relevant when considering restorations involving subgingival preparation edges. The objective of this study is to examine the utilization of knife-edge modified subgingival preparation procedures and monolithic zirconia restorative materials as potential strategies for the maintenance of periodontal and esthetic tissues over an extended length of time
Influence of Bisphosphonates on Implant and Peri-Implant Health: A Systematic Review and Meta Analysis Rikko Hudyono; Louis Krisna Wardhana; Adisty Restu Poetri; Taufan Bramantoro
Odonto : Dental Journal Vol. 13 No. 2 (2026): August 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.2.150-161

Abstract

Introduction: Bisphosphonates are widely prescribed for osteoporosis, raising concerns regarding their potential impact on dental implant survival. This systematic review and meta-analysis evaluated the association between bisphosphonate therapy and dental implant failure. Material and Methods: Following PRISMA guidelines and registered in PROSPERO (ID: 1136620), electronic searches of ScienceDirect, EBSCOhost, PubMed, MDPI, and Google Scholar were performed up to September 2025. Observational cohort studies comparing dental implant outcomes in bisphosphonate-exposed and non-exposed patient were included. Two reviewers performed data extraction and risk-of-bias assessment using the ROBINS-I. Pooled risk ratios (RRs) were calculated. Results: Six studies comprising 2,196 participants and 86 implant failures were included. Bisphosphonate exposure was associated with a significantly increased risk of implant failure (RR = 2.35; 95% CI, 1.24–4.44). with no heterogeneity (I² = 0%). Discussion: Despite the elevated relative risk, implant failure remained infrequent, resulting in a small absolute risk increase. The certainty of evidence was rated as moderate. Conclusion: Implant therapy should not be routinely avoided in bisphosphonate-treated patients, and individualized risk assessment is recommended. Further prospective studies are needed to clarify causality and patient-level risk modifiers.
KNIFE-EDGE MODIFIED SUBGINGIVAL CROWN PREPARATION: DENTAL PREPARATION ACCORDING TO BIOLOGICAL PRINCIPLES Rikko Hudyono; Helmi Fathurrahman; Nafisah Elok; Welly Anggarani; Rama Putranto
Odonto : Dental Journal Vol. 11 No. 2 (2024): December 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.2.305-316

Abstract

Fixed bridge and crown restorations are widely utilized in dental practice. The utilization of bridge as a substitute for implants is prevalent in several contexts. The crown preparation procedure has a crucial role in determining the long-term periodontal tissue health. Under-preparation frequently manifests in many clinical circumstances, resulting in the thickening of the prosthetic crown in the cervical region. The accumulation of plaque in subgingival preparations is an often seen issue. Given the progressive advancements in material technology and manufacturing procedures, it is imperative to critically evaluate the continued suitability of chamfer and shoulder preparation techniques in contemporary practice. This is particularly relevant when considering restorations involving subgingival preparation edges. The objective of this study is to examine the utilization of knife-edge modified subgingival preparation procedures and monolithic zirconia restorative materials as potential strategies for the maintenance of periodontal and esthetic tissues over an extended length of time
Influence of Bisphosphonates on Implant and Peri-Implant Health: A Systematic Review and Meta Analysis Rikko Hudyono; Louis Krisna Wardhana; Adisty Restu Poetri; Taufan Bramantoro
Odonto : Dental Journal Vol. 13 No. 2 (2026): August 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.2.150-161

Abstract

Introduction: Bisphosphonates are widely prescribed for osteoporosis, raising concerns regarding their potential impact on dental implant survival. This systematic review and meta-analysis evaluated the association between bisphosphonate therapy and dental implant failure. Material and Methods: Following PRISMA guidelines and registered in PROSPERO (ID: 1136620), electronic searches of ScienceDirect, EBSCOhost, PubMed, MDPI, and Google Scholar were performed up to September 2025. Observational cohort studies comparing dental implant outcomes in bisphosphonate-exposed and non-exposed patient were included. Two reviewers performed data extraction and risk-of-bias assessment using the ROBINS-I. Pooled risk ratios (RRs) were calculated. Results: Six studies comprising 2,196 participants and 86 implant failures were included. Bisphosphonate exposure was associated with a significantly increased risk of implant failure (RR = 2.35; 95% CI, 1.24–4.44). with no heterogeneity (I² = 0%). Discussion: Despite the elevated relative risk, implant failure remained infrequent, resulting in a small absolute risk increase. The certainty of evidence was rated as moderate. Conclusion: Implant therapy should not be routinely avoided in bisphosphonate-treated patients, and individualized risk assessment is recommended. Further prospective studies are needed to clarify causality and patient-level risk modifiers.