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Influence of Bisphosphonates on Implant and Peri-Implant Health: A Systematic Review and Meta Analysis Rikko Hudyono; Louis Krisna Wardhana; Adisty Restu Poetri; Taufan Bramantoro
Odonto : Dental Journal Vol 13, No 2 (2026): August 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.2.150-161

Introduction: Bisphosphonates are widely prescribed for osteoporosis, raising concerns regarding their potential impact on dental implant survival. This systematic review and meta-analysis evaluated the association between bisphosphonate therapy and dental implant failure. Material and Methods: Following PRISMA guidelines and registered in PROSPERO (ID: 1136620), electronic searches of ScienceDirect, EBSCOhost, PubMed, MDPI, and Google Scholar were performed up to September 2025. Observational cohort studies comparing dental implant outcomes in bisphosphonate-exposed and non-exposed patient were included. Two reviewers performed data extraction and risk-of-bias assessment using the ROBINS-I. Pooled risk ratios (RRs) were calculated. Results: Six studies comprising 2,196 participants and 86 implant failures were included. Bisphosphonate exposure was associated with a significantly increased risk of implant failure (RR = 2.35; 95% CI, 1.24–4.44). with no heterogeneity (I² = 0%). Discussion: Despite the elevated relative risk, implant failure remained infrequent, resulting in a small absolute risk increase. The certainty of evidence was rated as moderate. Conclusion: Implant therapy should not be routinely avoided in bisphosphonate-treated patients, and individualized risk assessment is recommended. Further prospective studies are needed to clarify causality and patient-level risk modifiers.

Influence of Bisphosphonates on Implant and Peri-Implant Health: A Systematic Review and Meta Analysis Rikko Hudyono; Louis Krisna Wardhana; Adisty Restu Poetri; Taufan Bramantoro
Odonto : Dental Journal Vol 13, No 2 (2026): August 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.2.150-161

Introduction: Bisphosphonates are widely prescribed for osteoporosis, raising concerns regarding their potential impact on dental implant survival. This systematic review and meta-analysis evaluated the association between bisphosphonate therapy and dental implant failure. Material and Methods: Following PRISMA guidelines and registered in PROSPERO (ID: 1136620), electronic searches of ScienceDirect, EBSCOhost, PubMed, MDPI, and Google Scholar were performed up to September 2025. Observational cohort studies comparing dental implant outcomes in bisphosphonate-exposed and non-exposed patient were included. Two reviewers performed data extraction and risk-of-bias assessment using the ROBINS-I. Pooled risk ratios (RRs) were calculated. Results: Six studies comprising 2,196 participants and 86 implant failures were included. Bisphosphonate exposure was associated with a significantly increased risk of implant failure (RR = 2.35; 95% CI, 1.24–4.44). with no heterogeneity (I² = 0%). Discussion: Despite the elevated relative risk, implant failure remained infrequent, resulting in a small absolute risk increase. The certainty of evidence was rated as moderate. Conclusion: Implant therapy should not be routinely avoided in bisphosphonate-treated patients, and individualized risk assessment is recommended. Further prospective studies are needed to clarify causality and patient-level risk modifiers.

Comparison of the effectiveness of education methods between quartet card games and lectures on students' oral health knowledge Nira Ardlina; Adisty Restu Poetri; Muqsitha Fitri Nugrahani; Rizki Widya Paramartha
Odonto : Dental Journal Vol. 12 No. 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.1-6

Background: This study aims to determine the differences in the effectiveness of education methods between the quartet card game method and the lectures method on the level of students' oral health knowledgeMethod: This study uses a cross-sectional study method. The subjects were 30 students of SD Islam Terpadu Asshodiqiyah Semarang by aged 11-12 years old. The subjects receive dental and oral health education. One group received education using the quartet card game method and the other group received education using the lectures method. The level of students' oral health knowledge was measured using a questionnaire (pre test and post test).Result: The Wilcoxon test results showed a significant difference between the pre-test and post-test scores of the quartet game method (p=0.036). There was a significant difference between the pre-test and post-test scores of the lecture method (p=0.002). The Mann-Whitney test results showed no significant difference between the post-test scores of the quartet card game method and the test scores of the lecture method (p=0.254).Conclusion: Quartet card games can be used as an alternative learning method that can increase student involvement in learning, resulting in good knowledge retention

Influence of Bisphosphonates on Implant and Peri-Implant Health: A Systematic Review and Meta Analysis Rikko Hudyono; Louis Krisna Wardhana; Adisty Restu Poetri; Taufan Bramantoro
Odonto : Dental Journal Vol. 13 No. 2 (2026): August 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.2.150-161

Introduction: Bisphosphonates are widely prescribed for osteoporosis, raising concerns regarding their potential impact on dental implant survival. This systematic review and meta-analysis evaluated the association between bisphosphonate therapy and dental implant failure. Material and Methods: Following PRISMA guidelines and registered in PROSPERO (ID: 1136620), electronic searches of ScienceDirect, EBSCOhost, PubMed, MDPI, and Google Scholar were performed up to September 2025. Observational cohort studies comparing dental implant outcomes in bisphosphonate-exposed and non-exposed patient were included. Two reviewers performed data extraction and risk-of-bias assessment using the ROBINS-I. Pooled risk ratios (RRs) were calculated. Results: Six studies comprising 2,196 participants and 86 implant failures were included. Bisphosphonate exposure was associated with a significantly increased risk of implant failure (RR = 2.35; 95% CI, 1.24–4.44). with no heterogeneity (I² = 0%). Discussion: Despite the elevated relative risk, implant failure remained infrequent, resulting in a small absolute risk increase. The certainty of evidence was rated as moderate. Conclusion: Implant therapy should not be routinely avoided in bisphosphonate-treated patients, and individualized risk assessment is recommended. Further prospective studies are needed to clarify causality and patient-level risk modifiers.

Comparison of the effectiveness of education methods between quartet card games and lectures on students' oral health knowledge Nira Ardlina; Adisty Restu Poetri; Muqsitha Fitri Nugrahani; Rizki Widya Paramartha
Odonto : Dental Journal Vol. 12 No. 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.1-6

Background: This study aims to determine the differences in the effectiveness of education methods between the quartet card game method and the lectures method on the level of students' oral health knowledgeMethod: This study uses a cross-sectional study method. The subjects were 30 students of SD Islam Terpadu Asshodiqiyah Semarang by aged 11-12 years old. The subjects receive dental and oral health education. One group received education using the quartet card game method and the other group received education using the lectures method. The level of students' oral health knowledge was measured using a questionnaire (pre test and post test).Result: The Wilcoxon test results showed a significant difference between the pre-test and post-test scores of the quartet game method (p=0.036). There was a significant difference between the pre-test and post-test scores of the lecture method (p=0.002). The Mann-Whitney test results showed no significant difference between the post-test scores of the quartet card game method and the test scores of the lecture method (p=0.254).Conclusion: Quartet card games can be used as an alternative learning method that can increase student involvement in learning, resulting in good knowledge retention

Influence of Bisphosphonates on Implant and Peri-Implant Health: A Systematic Review and Meta Analysis Rikko Hudyono; Louis Krisna Wardhana; Adisty Restu Poetri; Taufan Bramantoro
Odonto : Dental Journal Vol. 13 No. 2 (2026): August 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.13.2.150-161

Introduction: Bisphosphonates are widely prescribed for osteoporosis, raising concerns regarding their potential impact on dental implant survival. This systematic review and meta-analysis evaluated the association between bisphosphonate therapy and dental implant failure. Material and Methods: Following PRISMA guidelines and registered in PROSPERO (ID: 1136620), electronic searches of ScienceDirect, EBSCOhost, PubMed, MDPI, and Google Scholar were performed up to September 2025. Observational cohort studies comparing dental implant outcomes in bisphosphonate-exposed and non-exposed patient were included. Two reviewers performed data extraction and risk-of-bias assessment using the ROBINS-I. Pooled risk ratios (RRs) were calculated. Results: Six studies comprising 2,196 participants and 86 implant failures were included. Bisphosphonate exposure was associated with a significantly increased risk of implant failure (RR = 2.35; 95% CI, 1.24–4.44). with no heterogeneity (I² = 0%). Discussion: Despite the elevated relative risk, implant failure remained infrequent, resulting in a small absolute risk increase. The certainty of evidence was rated as moderate. Conclusion: Implant therapy should not be routinely avoided in bisphosphonate-treated patients, and individualized risk assessment is recommended. Further prospective studies are needed to clarify causality and patient-level risk modifiers.

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