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All Journal Biosaintifika: Journal of Biology & Biology Education
Salma Hilmy Rusydi Hashim
Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia
Agriculture, Biological Sciences & Forestry

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Modulatory Effects of Noni (Morinda citrifolia L.) Fruit Polysaccharide Syrup on IgG Production and T Cell Activity La Ode Muhammad Anwar; Ediati Sasmito; La Ode Akbar Rasydy; Tri Wahyuni Ismoyowati; Salma Hilmy Rusydi Hashim; Rohani Siregar; Emmelia Kristina Hutagaol; Cicilia Nony Ayuningsih Bratajaya; Aprilina Sartika; Dandi Sanjaya; Hajar Nur Fathur Rohmah; Joao Manuel Correia Ximenes
Biosaintifika: Journal of Biology & Biology Education Vol. 17 No. 2 (2025): August 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v17i2.26258

Abstract

Noni fruit containing polysaccharides, has the potential to be developed into pharmaceutical products such as SPF syrup. The content of noni fruit polysaccharides is known to increase the proliferation of T lymphocyte cells, the regulation of the immune system molecularly, especially with regard to antibodies (IgG), CD4+, and CD8+, is still not widely studied. The aim of this study was to assess the impact of SPF syrup on the modulation of immunoglobulin G (IgG) and T lymphocytes. The study was conducted on female Wistar rats aged 8-9 months, which were given SPF syrup orally at doses of 25, 50, and 100 mg/kgBB for 31 days. Mice were vaccinated against hepatitis B every week. Blood samples were taken on day 31 to measure IgG levels by the ELISA method and T cells (CD4+ and CD8+) by flow cytometry. The results showed that SPF administration had a significant effect on IgG levels (p<0.05), and there were no significant changes in T lymphocyte cells (CD4+, CD8+) (p>0.05). Histopathological examination showed that long-term induction of hepatitis B caused damage to the liver and kidney, but SPF did not affect the condition of these organs. SPF that contains polysaccharides can be an innovative component in immunostimulant formulations.
Co-Authors Aprilina Sartika Cicilia Nony Ayuningsih Bratajaya Dandi Sanjaya Ediati Sasmito Emmelia Kristina Hutagaol Hajar Nur Fathur Rohmah Ismoyowati, Tri Wahyuni Joao Manuel Correia Ximenes La Ode Akbar Rasydy La Ode Muhammad Anwar Rohani Siregar